65562-56-3Relevant academic research and scientific papers
An expeditious total synthesis of 50-Deoxy-toyocamycin and 50-Deoxysangivamycin
Dong, Xiangyou,Tang, Jie,Hu, Chen,Bai, Jiang,Ding, Haixin,Xiao, Qiang
, (2019/02/26)
In present paper, an expeditious total synthesis of naturally occurring 50-deoxytoyocamycin and 50-deoxysangivamycin was accomplished. Because of the introduction of a benzoyl group at N-6 of 4-amino-5-cyano-6-bromo-pyrrolo[2,3-d]pyrimidine, a Vorbrüggen glycosylation with 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose afforded a completely regioselective N-9 glycosylation product, which is unambiguously confirmed by X-ray diffraction analysis. All of the involved intermediates were well characterized by various spectra.
