6558-62-9 Usage
General Description
1-Methylimidazo[1,5-a]pyridine (1-MeIP) is a chemical compound belonging to the family of heterocyclic aromatic amines (HAAs) and is classified as a Group 2B carcinogen by the International Agency for Research on Cancer (IARC). It is formed during the cooking process of certain meats and fish at high temperatures, particularly when they are grilled, smoked, or charred. 1-MeIP is known to induce DNA damage and has been linked to an increased risk of developing cancer, particularly in the colon and prostate. It has also been found in tobacco smoke, and exposure to the compound has been associated with an elevated risk of lung cancer. In addition to its carcinogenic properties, 1-MeIP has been shown to have mutagenic and genotoxic effects, making it a concerning substance in terms of public health. Efforts to minimize exposure to 1-MeIP involve modifying cooking methods, avoiding overcooking, and avoiding smoking or charbroiling of foods.
Check Digit Verification of cas no
The CAS Registry Mumber 6558-62-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,5,5 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6558-62:
(6*6)+(5*5)+(4*5)+(3*8)+(2*6)+(1*2)=119
119 % 10 = 9
So 6558-62-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2/c1-7-8-4-2-3-5-10(8)6-9-7/h2-6H,1H3
6558-62-9Relevant articles and documents
The reaction of imidazo[1,5-a]pyridines with ninhydrin revisited
El-Abadelah, Mustafa M.,Awwadi, Firas F.,Abdullah, Ahmad H.,Voelter, Wolfgang
, p. 559 - 565 (2020)
The synthesis of 2,2′-(Imidazo[1,5-a]pyridine-1,3-diyl)bis(2-hydroxy-1H-indene-1,3(2H)-dione) (11) is achieved by reaction of imidazo[1,5-a]pyridine (7) with two equivalents of ninhydrin (1) at room temperature. The structure of this new 1,3-bis-adduct 11 is evidenced from HRMS and NMR spectral data and confirmed by single-crystal X-ray crystallography. Employment of equimolar amounts of 1 and 7 gave a separable mixture of the respective 1- A nd 3-monomeric adducts (9, 10).
