65588-60-5

Basic information

• Product Name: N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide
• Synonyms: benzenesulfonamide, N-[(3,4-dimethoxyphenyl)methyl]-4-methyl-
• CAS NO: 65588-60-5
• Molecular Formula: C₁₆H₁₉NO₄S
• Molecular Weight: 321.3914
• Mol File: 65588-60-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 475.1°C at 760 mmHg
• Flash Point: 241.1°C
• Density: 1.212g/cm³
• Vapor Pressure: 3.42E-09mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide(65588-60-5)
• EPA Substance Registry System: N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide(65588-60-5)

Safety Data

• Hazardous Substances Data: 65588-60-5(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5763-61-1 3,4-dimethoxybenzylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 100371-00-4 N-veratryl-β-alanine 
• 100253-85-8 N-veratryl-β-alanine nitrile 
• 102011-24-5 N-(toluene-4-sulfonyl)-N-veratryl-β-alanine 

Downstream Products

• 1527501-78-5 N-(3,4-dimethoxybenzyl)-N-(1H-indol-2-yl)-4-methylbenzenesulfonamide 
• 1431115-78-4 N-allyl-N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide 
• 1431116-78-7 (3S,4R,5R)-3-[3-(tert-butyldiphenylsilyloxy)propyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2,5-methano-1H-2-benzazepin-4-yl acetate 
• 1431116-72-1 (3S,4R,5R)-4-(benzyloxy)-3-[3-(benzyloxy)propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2,5-methano-1H-2-benzazepine 
• 1431116-60-7 methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate 
• 1431116-54-9 N-[(4S,2E)-7-(benzyloxy)-1-hydroxy-2-hepten-4-yl]-N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide 
• 1431116-48-1 (S)-N-{5-(benzyloxy)-1-(tert-butyldiphenylsilyloxy)pentan-2-yl}-N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide 
• 1431115-84-2 N-[(3E)-5-hydroxy-3-pentenyl]-N-(3,4-dimethoxybenzyl)-4-methylbenzenesulfonamide 
• 1431115-82-0 methyl (2E)-5-[N-(3,4-dimethoxybenzyl)-4-methylphenylsulfonamido]-2-pentenoate 

Relevant articles and documents

A synthetic N-alkyl sulfonamide derivatives

The invention discloses a method for synthesizing a N-alkyl sulfonamide derivative. The method comprises the following steps: adding a sulfonamide derivative, a water-soluble catalyst, an alkali, alcohol and a solvent into a reaction container; reacting the reaction mixture at 100-120 DEG C for several hours, cooling to room temperature; performing rotary evaporation to remove the solvent, and then separating by a column to obtain the target compound. The method of the invention starts from the sulfonamide derivative, and obtains the N-alkyl sulfonamide derivative through reaction with alcohol. The method of the invention adopts a water-soluble iridium complex as a catalyst; the reaction is carried out in water; and the target compound is obtained with a high yield. Therefore, the reaction meets the requirements for green chemistry, and the method has wide development prospects.

CuI-catalyzed coupling of gem-dibromovinylanilides and sulfonamides: An efficient method for the synthesis of 2-amidoindoles and indolo[1,2-a] quinazolines

A Cu(I)-catalyzed, intermolecular protocol for the synthesis of 2-amidoindoles and tetrahydroindolo[1,2-a]quinazolines in shorter time and high yields is reported. The key highlight of this disclosure is the formation of 2-amidoindole and tetrahydroindolo[1,2-a]quinazoline moieties directly from gem-dibromovinylanilides and sulfonamides in a one-pot fashion through the in situ formation of ynamides followed by a base-promoted intramolecular hydroamidation.