656-31-5

Basic information

• Product Name: 2-FLUOROPHENYLUREA
• Synonyms: 2-FLUOROPHENYLUREA;LABOTEST-BB LT00454556;Urea, (2-fluorophenyl)-;2-Fluorophenylurea 98%;2-Fluorophenylurea98%;1-(2-fluorophenyl)urea
• CAS NO: 656-31-5
• Molecular Formula: C₇H₇FN₂O
• Molecular Weight: 154.14
• EINECS: 211-513-6
• Mol File: 656-31-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 186-188°C
• Boiling Point: 228.1°C at 760 mmHg
• Flash Point: 91.7°C
• Appearance: /
• Density: 1.353g/cm³
• Vapor Pressure: 0.0748mmHg at 25°C
• Refractive Index: 1.608
• BRN: 2803651
• CAS DataBase Reference: 2-FLUOROPHENYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPHENYLUREA(656-31-5)
• EPA Substance Registry System: 2-FLUOROPHENYLUREA(656-31-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/22
• Safety Statements: 22-24/25
• Hazardous Substances Data: 656-31-5(Hazardous Substances Data)

Usage

General Description

2-Fluorophenylurea is a chemical compound with the molecular formula C7H7FN2O. It is a white solid that is sparingly soluble in water and other polar solvents. 2-Fluorophenylurea is an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also used as a reagent in chemical research and is known for its ability to react with various functional groups. The compound has been studied for its potential pharmacological and biological activities, although its specific applications and effects are still being investigated. Overall, 2-Fluorophenylurea is a versatile chemical with various synthetic and research applications.

InChI:InChI=1/C7H7FN2O/c8-5-3-1-2-4-6(5)10-7(9)11/h1-4H,(H3,9,10,11)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 61706-59-0 sodium fulminate 
• 917-61-3 sodium isocyanate 
• 16744-98-2 1-Fluoro-2-isocyanato-benzene 
• 656-32-6 N-(2-fluorophenyl)thiourea 
• 590-28-3 potassium cyanate 
• 348-51-6 1-chloro-2-fluorobenzene 
• 316180-88-8 C₁₄H₁₃FN₂O 

Downstream Products

• 210235-58-8 1-((E)-2-Cyano-3-oxo-3-phenyl-propenyl)-3-(2-fluoro-phenyl)-urea 
• 19678-17-2 N-(2-Fluor-phenyl)-N'-cyanacetyl-harnstoff 
• 1228004-39-4 ethyl 2-(2-fluorophenylamino)-4-(trifluoromethyl)oxazole-5-carboxylate 

Relevant articles and documents

Synthesis of Five-Membered Cyclic Guanidines via Cascade [3 + 2] Cycloaddition of α-Haloamides with Organo-cyanamides

The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and α-haloamides under mild conditions in good to excellent yields (up to 99%). The corresponding cyclic guanidines could be easily transformed into hydantoins via hydrolysis.

Synthesis and crystal structure of N-(3-benzylamino-2-cyano-3- methylthioacrylyl)-N′-(substituted phenyl)ureas

Phenylurea groups were introduced into the frame of traditional cyanoacrylate and a series of N-(3-benzylamino-2-cyano-3-methylthioacrylyl)- N′-(substituted phenyl)ureas were synthesized. All compounds are new and their structures were confirmed by 1H NMR, 13C NMR and mass spectral analyses.

Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions

A facile synthesis of unsymmetrical N,N′-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.