656-31-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Fluorophenylurea is used as a key intermediate in the production of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of medicinal compounds with potential applications in treating various diseases and conditions.
Used in Organic Compound Synthesis:
As a versatile chemical intermediate, 2-Fluorophenylurea is employed in the synthesis of various organic compounds for different industries, including agriculture, materials science, and specialty chemicals. Its ability to react with different functional groups makes it a valuable building block for creating complex organic molecules with specific properties and applications.
Used in Chemical Research:
2-Fluorophenylurea is utilized as a reagent in chemical research, enabling scientists to explore its reactivity and potential interactions with other compounds. This research helps in understanding the fundamental chemical properties of the compound and contributes to the discovery of new reactions and synthetic pathways.
Used in Investigation of Pharmacological and Biological Activities:
2-FLUOROPHENYLUREA is being studied for its potential pharmacological and biological activities, with the aim of identifying its specific applications and effects. This research could lead to the development of new therapeutic agents or the enhancement of existing ones, ultimately benefiting the medical and pharmaceutical industries.

InChI:InChI=1/C7H7FN2O/c8-5-3-1-2-4-6(5)10-7(9)11/h1-4H,(H3,9,10,11)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 61706-59-0 sodium fulminate 
• 917-61-3 sodium isocyanate 
• 316180-88-8 C₁₄H₁₃FN₂O 
• 348-51-6 1-chloro-2-fluorobenzene 
• 590-28-3 potassium cyanate 
• 16744-98-2 1-Fluoro-2-isocyanato-benzene 
• 656-32-6 N-(2-fluorophenyl)thiourea 

Downstream Products

• 210235-58-8 1-((E)-2-Cyano-3-oxo-3-phenyl-propenyl)-3-(2-fluoro-phenyl)-urea 
• 19678-17-2 N-(2-Fluor-phenyl)-N'-cyanacetyl-harnstoff 
• 1228004-39-4 ethyl 2-(2-fluorophenylamino)-4-(trifluoromethyl)oxazole-5-carboxylate 

Relevant academic research and scientific papers

Synthesis of Five-Membered Cyclic Guanidines via Cascade [3 + 2] Cycloaddition of α-Haloamides with Organo-cyanamides

The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and α-haloamides under mild conditions in good to excellent yields (up to 99%). The corresponding cyclic guanidines could be easily transformed into hydantoins via hydrolysis.

Selective and facile oxidative desulfurization of thioureas and thiobarbituric acids with singlet molecular oxygen generated from trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane

An efficient and facile procedure using trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane has been developed for oxidative desulfurization of thioureas and thiobarbituric acids. The reactions proceeded smoothly very fast under mild conditions in basic media at room temperature to afford the respective ureas in excellent yields. Simple procedure and work up, mild conditions, high yields, short reaction times, use of highly potent and non-toxic oxidant are the main merits of the present method.

Synthesis and crystal structure of N-(3-benzylamino-2-cyano-3- methylthioacrylyl)-N′-(substituted phenyl)ureas

Phenylurea groups were introduced into the frame of traditional cyanoacrylate and a series of N-(3-benzylamino-2-cyano-3-methylthioacrylyl)- N′-(substituted phenyl)ureas were synthesized. All compounds are new and their structures were confirmed by 1H NMR, 13C NMR and mass spectral analyses.

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions

A facile synthesis of unsymmetrical N,N′-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.

Chalconsemicarbazone: A new scaffold for antiepileptic drug discovery

During our investigation in the area of epileptic drug discovery, we have identified that the available conventional antiepileptic drugs are effective in 60-80% patients and in specific type of seizures and having various undesirable side effects. But in present time a new class aryl semicarbazone is emerged as new pharmacophore in epileptic drug discovery having broad spectrum activity. On the bases of work done in this area we have applied hybridization of pharmacophore strategy of drug design and developed a new pharmacophore. We have also designed a scheme for synthesizing such pharmacophore and performed their pharmacological screening for the protection of seizures, behavioral study and CNS activity. The compound 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl) allylidene]-4-(2-fluorophenyl) semicarbazide (8) emerged as the most active prototype molecule in all the models.

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: New templates among the CB1 cannabinoid receptor inverse agonists

New 1-benzhydryl-3-phenylurea derivatives and their 1-benzhydryl-3- phenylthiourea isosteres were synthesized and evaluated for their human CB 1 and CB2 cannabinoid receptor affinity. These compounds proved to be selective CB1 cannabinoid receptor ligands, acting as inverse agonists in a [35S]-GTPγS assay. The affinity of 3,5,5′-triphenylimidazolidine-2,4-dione and 3,5,5′-triphenyl-2- thioxoimidazolidin-4-one derivatives, possessing the 1-benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea moiety, respectively, was also evaluated. In conclusion, the 1-benzhydryl-3-phenylurea scaffold seems to be a new interesting template of CB1 cannabinoid receptor inverse agonists.