65609-28-1

Usage

Uses

Used in Agricultural Industry:
1-(1,3-benzodioxol-5-ylmethyl)urea is used as an insect growth regulator and pesticide for controlling the growth and reproduction of pests such as aphids, whiteflies, and caterpillars. It works by inhibiting the development of insects at the nymphal and pupal stages, effectively disrupting their life cycle and preventing them from reaching adulthood. This helps in reducing the damage caused by these pests to crops and ensures a healthier yield.
Additionally, 1-(1,3-benzodioxol-5-ylmethyl)urea is used in various formulations, including sprays, baits, and granules, to cater to different methods of application in agriculture. Its low toxicity to mammals and safety for use in food crops when used according to labeled instructions make it a preferred choice for pest control in the industry.

Upstream product

• 590-28-3 potassium cyanate 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 57-13-6 urea 
• 2620-49-7 3,4-methylenedioxybenzylamine hydrochloride 

Downstream Products

• 1442442-89-8 C₂₈H₂₆N₂O₆ 
• 1616091-74-7 (2-(1-(4-methoxybenzyl)-5-((benzo[d][1,3]dioxol-6-yl)methyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine 
• 1616092-31-9 C₂₁H₂₃N₅O₅ 
• 1616092-18-2 C₂₀H₁₉N₃O₅S 

Relevant academic research and scientific papers

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

MONOSUBSTITUTED UREA DERIVATIVES AS A SELF-TANNING SUBSTANCE

The present invention relates to the use of monosubstiuted urea derivatives of the formula I as self-tanning substance, for increasing melanin synthesis, for improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these urea derivatives.

Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors

The sodium iodide symporter (NIS) is responsible for the accumulation of iodide in the thyroid gland. This transport process is involved in numerous thyroid dysfunctions and is the basis for human contamination in the case of exposure to radioactive iodine species. 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones were recently discovered by high-throughput screening as the first NIS inhibitors. Described herein are the synthesis and evaluation of 115 derivatives with structural modifications at five key positions on the pyrimidone core. This study provides extensive structure-activity relationships for this new class of inhibitors that will serve as a basis for further development of compounds with invivo efficacy and adequate pharmacokinetic properties. In addition, the SAR investigation provided a more potent compound, which exhibits an IC50 value of 3.2nM in a rat thyroid cell line (FRTL5).