65609-33-8Relevant academic research and scientific papers
Self-Assembly of n-Alkyl- and Aryl-Side Chain Ureas and Their Derivatives as Evidenced by SEM and X-ray Analysis
Kulikov, Oleg V.,Siriwardane, Dumindika A.,McCandless, Gregory T.,Barnes, Charles,Sevryugina, Yulia V.,Desousa, Joseph D.,Wu, Jingbo,Sommer, Roger,Novak, Bruce M.
, p. 7511 - 7518 (2015)
A small library of ureas and related compounds was synthesized and examined by scanning electron microscopy (SEM), single-crystal X-ray diffraction, powder X-ray (pXRD), and polarized optical microscopy (POM) techniques in order to elucidate the factors controlling their self-assembly in the solid state. Inspection of the 12 solid-state structures revealed that molecules in the crystal lattice are held together by intermolecular H-bonding, π-π stacking as well as C-H/π interactions. The same interactions are likely responsible for the formation of supramolecular aggregates (e.g. sheet-like assemblies, micro- and nano-fibers, and the porous networks easily identifiable by SEM technique) and in certain cases led to the small molecules gelation.
Capsaicin-like analogue induced selective apoptosis in A2058 melanoma cells: Design, synthesis and molecular modeling
Pereira, Gustavo José Vasco,Tavares, Maurício Temotheo,Azevedo, Ricardo Alexandre,Martins, Barbara Behr,Cunha, Micael Rodrigues,Bhardwaj, Rajesh,Cury, Yara,Zambelli, Vanessa Olzon,Barbosa, Euzébio Guimar?es,Hediger, Matthias A.,Parise-Filho, Roberto
, p. 2893 - 2904 (2019/05/22)
The use of molecules inspired by natural scaffolds has proven to be a very promising and efficient method of drug discovery. In this work, capsaicin, a natural product from Capsicum peppers with antitumor properties, was used as a prototype to obtain urea
