65610-13-1

Basic information

• Product Name: 3-FLUOROPHTHALODINITRILE
• Synonyms: 1,2-DICYANO-3-FLUOROBENZENE;3-FLUOROPHTHALODINITRILE;3-FLUOROPHTHALONITRILE;1,2-Benzenedicarbonitrile,3-fluoro-(9CI);3-Fluoro-1,2-benzenedicarbonitrile;3-Fluorophthalonitrille;3-fluorobenzene-1,2-dicarbonitrile
• CAS NO: 65610-13-1
• Molecular Formula: C₈H₃FN₂
• Molecular Weight: 146.12
• Product Categories: HALIDE;NITRILE;Aromatic Nitriles;Fluorine series
• Mol File: 65610-13-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 295℃
• Flash Point: 132℃
• Appearance: light yellow crystall powder
• Density: 1.27
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-FLUOROPHTHALODINITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROPHTHALODINITRILE(65610-13-1)
• EPA Substance Registry System: 3-FLUOROPHTHALODINITRILE(65610-13-1)

Safety Data

• Hazardous Substances Data: 65610-13-1(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystall powder

InChI:InChI=1/C8H3FN2/c9-8-3-1-2-6(4-10)7(8)5-11/h1-3H

Upstream product

• 77326-36-4 2-amino-6-fluorobenzonitrile 
• 151-50-8 potassium cyanide 

Downstream Products

• 1240518-61-9 N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(difluoromethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide 
• 1240518-60-8 1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate 
• 1240518-63-1 N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide 
• 1240518-62-0 1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(hydroxymethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate 
• 1240518-59-5 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate 
• 1240518-64-2 1,1-dimethylethyl ({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate 
• 1240518-58-4 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate 
• 1240518-65-3 N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide 
• 1240518-84-6 C₂₀H₁₆ClN₅O₂S₂ 
• 1240518-81-3 N-[(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 
• 1240517-76-3 N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 
• 1240517-79-6 N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxy-1-methylethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 
• 1240517-78-5 N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 
• 1240518-66-4 N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide 

Relevant articles and documents

Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines

A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, ethyl cyanoformate or allylic bromides (39 examples, 62–99 % yield) is reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50 °C, 4 h) provided the corresponding nitriles (36 examples, 73–99 % yield). Conversions of these nitriles to valuable heterocycles are reported, and a tentative mechanism is proposed.