65611-54-3Relevant academic research and scientific papers
Me2Zn-mediated addition of acetylenes to aldehydes and ketones
Cozzi, Pier Giorgio,Rudolph, Jens,Bolm, Carsten,Norrby, Per-Ola,Tomasini, Claudia
, p. 5733 - 5736 (2005)
Contrary to expectations, commercially available 2 M Me2Zn in toluene is able to promote the addition of phenylacetylene to aldehydes and ketones. This reactivity is determined by a new, unprecedented mechanism, which involves activation of the zinc reagent via coordination with carbonyl substrates that behave "ligand like". Broad scope, high tolerance to functional groups, and a simple procedure make this new method highly interesting for the synthetic chemist.
