65618-71-5

Downstream Products

• 99289-53-9 4-(4-Chloro-phenyl)-4-dimethylamino-1-phenethyl-cyclohexanol 
• 99289-54-0 4-(4-Chloro-phenyl)-4-dimethylamino-1-phenethyl-cyclohexanol 
• 70895-14-6 4-(4-Chloro-phenyl)-1-(2-cyclopentyl-ethyl)-4-dimethylamino-cyclohexanol 
• 70895-14-6 4-(4-Chloro-phenyl)-1-(2-cyclopentyl-ethyl)-4-dimethylamino-cyclohexanol 
• 68967-87-3 [1-(4-chloro-phenyl)-4-morpholin-4-yl-cyclohexyl]-dimethyl-amine 
• 65619-98-9 4-(p-chlorophenyl)-2-methyl-4-dimethylaminocyclohexanone 
• 99289-55-1 4-(4-Chloro-phenyl)-1-[2-(4-chloro-phenyl)-ethyl]-4-dimethylamino-cyclohexanol 
• 99289-56-2 4-(4-Chloro-phenyl)-1-[2-(4-chloro-phenyl)-ethyl]-4-dimethylamino-cyclohexanol 
• 792855-85-7 1-Allyl-4-(4-chloro-phenyl)-4-dimethylamino-cyclohexanol 
• 99289-44-8 1-Allyl-4-(4-chloro-phenyl)-4-dimethylamino-cyclohexanol 
• 76825-06-4 trans-4-(dimethylamino)-4-(p-chlorophenyl)cyclohexanol 
• 99289-49-3 4-(4-Chloro-phenyl)-4-dimethylamino-1-pent-4-enyl-cyclohexanol 
• 99289-50-6 4-(4-Chloro-phenyl)-4-dimethylamino-1-pent-4-enyl-cyclohexanol 
• 99289-51-7 1-Benzyl-4-(4-chloro-phenyl)-4-dimethylamino-cyclohexanol 

Relevant academic research and scientific papers

4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use

Novel 4-aminocyclohexanols are formulated into pharmaceutical compositions for analgetic purposes in mammals in need of said treatment.

Compounds, compositions and method of use

4-Amino-4-cyclohexan-1-ols are formulated into pharmaceutical compositions for the relief of pain in mammals in need of said treatment.

Analgetic compounds, compositions and process of treatment

Novel compounds of the formula: STR1 wherein R1 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, CH2 -alkenyl wherein alkenyl is from 2 to 4 carbon atoms, inclusive, cycloalkyl of from 3 to 6 carbon atoms, inclusive, cycloalkylmethyl of from 3 to 6 carbon atoms, inclusive; R2 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, inclusive, with the proviso that R1 and R2 cannot both be hydrogen at the same time; Y is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive, halogen, trifluoromethyl, hydroxy, alkanoyloxy from 2 to 5 carbon atoms, inclusive, alkoxy of from 1 to 4 carbon atoms, inclusive, cycloalkyloxy of from 3 to 6 carbon atoms, inclusive, benzyloxy; m is an integer 0, 1, 2; R5 is a variable consisting of hydrogen and alkyl of from 1 to 4 carbon atoms, inclusive; R3 is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive; R4 is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive, CH2 -alkenyl wherein alkenyl is of from 2 to 4 carbon atoms, inclusive, and arylalkyl wherein alkyl is from 1 to 4 carbon atoms, inclusive, and aryl is STR2 WHEREIN Y' is CF3, halogen, alkyl of 1 to 4 carbon atoms, inclusive, and alkoxy of from 1 to 4 carbon atoms, inclusive; and R3 and R4 when taken together with the nitrogen atom to which they are attached can form saturated heterocycles of from 5 to 7 ring members, a second hetero atom of said ring can be oxygen or nitrogen, e.g., morpholine, piperazine, and said heterocycles can be monosubstituted having a total of up to 9 carbon atoms, with the proviso that when STR3 is pyrrolidinyl, then m = 1, 2, having analgetic activity in humans and animals are prepared in unit dosage forms. The compositions are useful in relieving pain by administering orally, parenterally, and rectally to humans and animals.