65618-88-4

Basic information

• Product Name: 4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE
• Synonyms: 4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE;1-(2-chlorophenyl)-4-oxocyclohexanecarbonitrile
• CAS NO: 65618-88-4
• Molecular Formula: C₁₃H₁₂ClNO
• Molecular Weight: 233.697
• Mol File: 65618-88-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE(65618-88-4)
• EPA Substance Registry System: 4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE(65618-88-4)

Safety Data

• Hazardous Substances Data: 65618-88-4(Hazardous Substances Data)

Usage

General Description

4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE is a chemical compound that consists of a cyclohexanone ring with a cyanide group and a 2-chlorophenyl group attached. It is classified as a cyclohexanone derivative and is commonly used as an intermediate in the synthesis of various organic compounds. This chemical may be used in pharmaceutical research and drug development due to its potential to interact with biological systems. It may also have industrial applications in the production of specialty chemicals and materials. However, it is important to handle and use this compound with caution, as it may have hazardous properties and require proper safety measures during handling and storage.

Upstream product

• 65618-86-2 dimethyl-4-(o-chlorophenyl)-4-cyanopimelate 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 56326-94-4 methyl 5-cyano-5-(4-chlorophenyl)-2-oxocyclohexanecarboxylate 
• 65618-87-3 2-carbomethoxy-4-cyano-4-(o-chlorophenyl)cyclohexanone 

Downstream Products

• 37416-25-4 2-[4-(2-Chloro-phenyl)-4-cyano-cyclohex-1-enyl]-propionic acid ethyl ester 
• 37416-30-1 2-[4-(2-Chloro-phenyl)-4-cyano-cyclohex-1-enyl]-propionic acid 
• 77253-88-4 4-(o-chlorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal 
• 65618-91-9 4-(o-chlorophenyl)-4-isocyanatocyclohexanone, ethylene ketal 
• 65618-90-8 4-carboxy-4-(o-chlorophenyl)cyclohexanone, ethylene ketal 
• 65618-92-0 4-(o-chlorophenyl)-4-methylaminocyclohexanone, ethylene ketal 
• 65618-89-5 4-(o-chlorophenyl)-4-cyanocyclohexanone, ethylene ketal 

Relevant articles and documents

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.