65618-88-4

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE is used as a chemical intermediate for the synthesis of pharmaceutical compounds, leveraging its ability to interact with biological systems. This interaction is crucial for the development of new drugs and therapeutic agents.
Used in Industrial Production of Specialty Chemicals and Materials:
In the chemical industry, 4-CYANO-4-(2-CHLOROPHENYL)CYCLOHEXANONE serves as a key intermediate in the production of specialty chemicals and materials, contributing to the creation of innovative and high-performance products.

Upstream product

• 56326-94-4 methyl 5-cyano-5-(4-chlorophenyl)-2-oxocyclohexanecarboxylate 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 65618-86-2 dimethyl-4-(o-chlorophenyl)-4-cyanopimelate 
• 65618-87-3 2-carbomethoxy-4-cyano-4-(o-chlorophenyl)cyclohexanone 

Downstream Products

• 37416-30-1 2-[4-(2-Chloro-phenyl)-4-cyano-cyclohex-1-enyl]-propionic acid 
• 77253-88-4 4-(o-chlorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal 
• 65618-91-9 4-(o-chlorophenyl)-4-isocyanatocyclohexanone, ethylene ketal 
• 65618-90-8 4-carboxy-4-(o-chlorophenyl)cyclohexanone, ethylene ketal 
• 65618-92-0 4-(o-chlorophenyl)-4-methylaminocyclohexanone, ethylene ketal 
• 65618-89-5 4-(o-chlorophenyl)-4-cyanocyclohexanone, ethylene ketal 
• 37416-25-4 2-[4-(2-Chloro-phenyl)-4-cyano-cyclohex-1-enyl]-propionic acid ethyl ester 

Relevant academic research and scientific papers

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

Potent bradykinin B1 receptor antagonists: 4-Substituted phenyl cyclohexanes

Selective bradykinin (BK) B1 receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B1 receptor antagonists.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.

4-Amino-4-phenylcyclohexanone ketal compositions and process of use

A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.