65619-01-4

Usage

Uses

Used in Pharmaceutical Research:
4-CYANO-4-(4-METHYLPHENYL)CYCLOHEXANONE is utilized as a key building block in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of a wide range of medicinal compounds with potential applications in treating various diseases and conditions.
Used in Agrochemical Development:
In the agrochemical industry, 4-CYANO-4-(4-METHYLPHENYL)CYCLOHEXANONE serves as a crucial intermediate in the synthesis of various agrochemicals. Its incorporation aids in the development of pesticides, herbicides, and other agricultural chemicals that are essential for enhancing crop protection and yield.
Used in Material Science:
4-CYANO-4-(4-METHYLPHENYL)CYCLOHEXANONE holds potential in material science for the development of new materials with unique properties. Its structural attributes make it a valuable component in the synthesis of advanced materials for various applications, including high-performance polymers and composites.
Used as a Chemical Reaction Reagent:
In the realm of chemical reactions, 4-CYANO-4-(4-METHYLPHENYL)CYCLOHEXANONE functions as a reagent, facilitating specific transformations and processes. Its presence can enhance the efficiency and selectivity of certain reactions, making it a valuable tool in the synthesis of complex organic molecules.

Upstream product

• 65618-99-7 4-Cyano-4-(p-tolyl)-pimelinsaeuredimethylester 
• 56326-94-4 methyl 5-cyano-5-(4-chlorophenyl)-2-oxocyclohexanecarboxylate 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 65619-00-3 2-carbomethoxy-4-cyano-4-(p-tolyl)cyclohexanone 

Downstream Products

• 65619-02-5 4-cyano-4-(p-tolyl)cyclohexanone, ethylene ketal 
• 77253-86-2 4-dimethylamino-4-(p-tolyl)cyclohexan-1-one, ethylene ketal 
• 65619-03-6 4-isocyanato-4-(p-tolyl)cyclohexanone, ethylene ketal 
• 65653-88-5 4-carboxy-4-(p-tolyl)cyclohexanone, ethylene ketal 
• 65619-04-7 4-methylamino-4-(p-tolyl)cyclohexanone, ethylene ketal 

Relevant academic research and scientific papers

DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula (I), their use and pharmaceutical compositions comprising them.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.

4-Amino-4-phenylcyclohexanone ketal compositions and process of use

A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.