65619-09-2

Usage

Uses

Used in Organic Synthesis:
4-CYANO-4-(2-METHYLPHENYL)CYCLOHEXANONE is used as a building block for the production of various products in organic synthesis.
Used in Pharmaceutical Research:
4-CYANO-4-(2-METHYLPHENYL)CYCLOHEXANONE is used as a building block for the production of various pharmaceutical products.
Used in Chemical Engineering:
4-CYANO-4-(2-METHYLPHENYL)CYCLOHEXANONE may have potential applications in the development of new materials or as a chemical intermediate in the manufacturing of other compounds in the field of chemical engineering.

Upstream product

• 56326-94-4 methyl 5-cyano-5-(4-chlorophenyl)-2-oxocyclohexanecarboxylate 
• 22364-68-7 2-tolylmethylnitrile 
• 65619-07-0 4-cyano-4-o-tolyl-heptanedioic acid dimethyl ester 
• 65619-08-1 5-cyano-2-oxo-5-o-tolyl-cyclohexanecarboxylic acid methyl ester 

Downstream Products

• 79741-39-2 Dimethyl-(8-o-tolyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amine 
• 79741-32-5 Methyl-(8-o-tolyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amine 
• 65619-12-7 4-isocyanato-4-(o-tolyl)cyclohexanone, ethylene ketal 
• 65619-11-6 4-carboxy-4-(o-tolyl)cyclohexanone, ethylene ketal 
• 65619-10-5 4-cyano-4-(o-tolyl)cyclohexanone, ethylene ketal 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOUNDS

This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof

This application relates to phenyl-substituted 1,2,3,4-tetrahydrocarbazoles and to their use as anti-depressant agents useful in the treatment of mental depression of either endogenous or reactive nature.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.

4-Amino-4-phenylcyclohexanone ketal compositions and process of use

A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.