65619-31-0 Usage
General Description
The chemical 4-CYANO-4-(2,4-DICHLOROPHENYL)CYCLOHEXANONE is a cyclohexanone derivative with a cyano and dichlorophenyl group attached to the cyclohexanone ring. It is a white to light yellow solid, and it is used as an intermediate in the synthesis of various organic compounds. The chemical structure and functional groups present in the molecule make it useful in the development of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it is often used as a building block in organic synthesis due to its reactivity and versatility in forming chemical bonds. Overall, 4-CYANO-4-(2,4-DICHLOROPHENYL)CYCLOHEXANONE has applications in various industries and is an important compound in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 65619-31-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,6,1 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 65619-31:
(7*6)+(6*5)+(5*6)+(4*1)+(3*9)+(2*3)+(1*1)=140
140 % 10 = 0
So 65619-31-0 is a valid CAS Registry Number.
65619-31-0Relevant articles and documents
4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring
Lednicer, Daniel,VonVoigtlander, Philip F.,Emmert, D. Edward
, p. 424 - 430 (2007/10/02)
Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.