656235-44-8

Basic information

• Product Name: Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
• Synonyms: Boronic acid, (2-cyano-6-fluorophenyl)- (9CI);Boronic acid, B-(2-cyano-6-fluorophenyl)-
• CAS NO: 656235-44-8
• Molecular Formula: C₇H₅BFNO₂
• Molecular Weight: 164.9295032
• Product Categories: HALIDE
• Mol File: 656235-44-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 367.7±52.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.77±0.58(Predicted)
• CAS DataBase Reference: Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)(656235-44-8)
• EPA Substance Registry System: Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)(656235-44-8)

Safety Data

• Hazardous Substances Data: 656235-44-8(Hazardous Substances Data)

Usage

Uses

2-Cyano-6-fluorophenylboronic acid

Upstream product

• 403-54-3 m-Fluorobenzonitrile 

Downstream Products

• 425379-21-1 5'-bromo-6,2'-difluorobiphenyl-2-carbonitrile 
• 425379-16-4 2-bromo-3-fluorobenzonitrile 
• 132715-70-9 2-Bromo-3-fluorobenzamide 

Relevant articles and documents

AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS

The present invention relates to a7 nicotinic receptor agonists of formula (la) or (lb) as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula (la) or (lb). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7nicotinic receptor agonist of formula (la) or (lb).

Facile Synthesis of 2-Bromo-3-fluorobenzonitrile: An Application and Study of the Halodeboronation of Aryl Boronic Acids

A scaleable synthesis of 2-bromo-3-fluorobenzonitrile via the NaOMe-catalyzed bromodeboronation of 2-cyano-6-fluorophenylboronic acid was developed. The generality of this transformation was demonstrated through the halodeboronation of a series of aryl boronic acids. Both aryl bromides and aryl chlorides were formed in good to excellent yields when the corresponding aryl boronic acid was treated with 1,3-dihalo-5,5-dimethylhydantoin and 5 mol % NaOMe.