656235-44-8Relevant academic research and scientific papers
AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS
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Page/Page column 44, (2010/11/30)
The present invention relates to a7 nicotinic receptor agonists of formula (la) or (lb) as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula (la) or (lb). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7nicotinic receptor agonist of formula (la) or (lb).
Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4] triazine: Synthesis of an α2/3-selective GABA agonist
Gauthier Jr., Donald R.,Limanto, John,Devine, Paul N.,Desmond, Richard A.,Szumigala Jr., Ronald H.,Foster, Bruce S.,Volante
, p. 5938 - 5945 (2007/10/03)
A convergent, practical, and efficient synthesis of 2′,6-difluoro- 5′-[3-(1-hydroxy-1-methylethy)-imidazo[1,2-b][1,2,4]triazin-7-yl] biphenyl-2-carbonitrile (1), an orally active GABAA dag-selective agonist, is described. The seven-step, chromatography-fr
Facile Synthesis of 2-Bromo-3-fluorobenzonitrile: An Application and Study of the Halodeboronation of Aryl Boronic Acids
Szumigala Jr., Ronald H.,Devine, Paul N.,Gauthier Jr., Donald R.,Volante
, p. 566 - 569 (2007/10/03)
A scaleable synthesis of 2-bromo-3-fluorobenzonitrile via the NaOMe-catalyzed bromodeboronation of 2-cyano-6-fluorophenylboronic acid was developed. The generality of this transformation was demonstrated through the halodeboronation of a series of aryl boronic acids. Both aryl bromides and aryl chlorides were formed in good to excellent yields when the corresponding aryl boronic acid was treated with 1,3-dihalo-5,5-dimethylhydantoin and 5 mol % NaOMe.
