656249-68-2Relevant articles and documents
Solution-phase synthesis of phosphorothioate oligonucleotides using a solid-supported acyl chloride with H-phosphonate chemistry
Adamo, Ilaria,Dueymes, Cecile,Schoenberger, Andreas,Navarro, Aude-Emmanuelle,Meyer, Albert,Lange, Meinolf,Imbach, Jean-Louis,Link, Fritz,Morvan, Francois,Vasseur, Jean-Jacques
, p. 436 - 448 (2007/10/03)
The synthesis of oligonucleotides from dimers to a hexamer by a H-phosphonate approach in solution using solid-supported acyl chloride is reported herein. This strategy avoids the use of chromatography. The work-ups have been simplified and involve filtra