656254-53-4

Upstream product

• 220355-87-3 5,15-bis(3,5-bis(octyloxy)phenyl)porphyrinatozinc(II) 
• 5970-45-6 zinc(II) acetate dihydrate 

Downstream Products

• 942360-47-6 [5,15-bis(3,5-dioctyloxyphenyl)-10,20-bis(trihexylsilanylethynyl)porphyrinato]zinc(II) 
• 348081-90-3 (15-(3,5-dioctyloxyphenyl)-(CH₃)4-(C₆H₁₃)4-Zn(II)-porphyrin)C₆H₄CCCCC₆H₄(15-(3,5-dioctyloxyphenyl)-(CH₃)4-(C₆H₁₃)4-Zn(II)-porphyrin) 
• 237396-96-2 (10,15,20-(3,5-di-tert-butylphenyl)-Zn(II)-porphyrin)C₆H₄CCCCC₆H₄(10,15,20-(3,5-di-tert-butylphenyl)-Zn(II)-porphyrin) 

Relevant academic research and scientific papers

A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy

Conjugated polymers have been increasingly studied for photothermal therapy (PTT) because of their merits including large absorption coefficient, facile tuning of exciton energy dissipation through nonradiative decay, and good therapeutic efficacy. The high photothermal conversion efficiency (PCE) is the key to realize efficient PTT. Herein, a donor–acceptor (D–A) structured porphyrin-containing conjugated polymer (PorCP) is reported for efficient PTT in vitro and in vivo. The D–A structure introduces intramolecular charge transfer along the backbone, resulting in redshifted Q band, broadened absorption, and increased extinction coefficient as compared to the state-of-art porphyrin-based photothermal reagent. Through nanoencapsulation, the dense packing of a large number of PorCP molecules in a single nanoparticle (NP) leads to favorable nonradiative decay, good photostability, and high extinction coefficient of 4.23 × 104m?1 cm?1 at 800 nm based on porphyrin molar concentration and the highest PCE of 63.8% among conjugated polymer NPs. With the aid of coloaded fluorescent conjugated polymer, the cellular uptake and distribution of the PorCP in vitro can be clearly visualized, which also shows effective photothermal tumor ablation in vitro and in vivo. This research indicates a new design route of conjugated polymer-based photothermal therapeutic materials for potential personalized theranostic nanomedicine.

Synthesis and linear and nonlinear optical properties of low-melting π-extended porphyrins

A large and diverse library of trans-A2B2 and A 2BC-porphyrins possessing two arylethynyl substituents at the meso positions has been efficiently synthesized and tested for their two-photon absorption (2PA) behavior. All compounds fall into three general types A-π-A, D-π-D or D-π-A, where A is an electron-acceptor and D is an electron-donor moiety. These porphyrins contain two polyalkoxyaryl substituents, resulting in very low melting points (typically 110-125 °C) and superb solubility in non-polar solvents. Some of these porphyrins exhibit two different crystal phases in addition to an isotropic liquid state. Their linear and nonlinear optical properties were thoroughly elucidated and analyzed. π-Extended porphyrins emit light in the NIR and have moderate triplet state lifetimes. The increase of 2PA cross-section in the Soret region for porphyrins bearing strong electron-donating groups has been attributed to resonance enhancement (caused by intensification, redshift and broadening of the lowest Q-band) of gerade-gerade transition. The combination of high two-photon absorption cross-sections (>500 GM) and low melting points makes them perfect candidates for nonlinear optical materials in the 600-900 nm range.