65626-52-0

Basic information

• Product Name: C₄H₄N₃^(1-)
• Synonyms: C₄H₄N₃^(1-)
• CAS NO: 65626-52-0
• Molecular Weight: 94.0959
• Mol File: 65626-52-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄H₄N₃^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₄H₄N₃^(1-)(65626-52-0)
• EPA Substance Registry System: C₄H₄N₃^(1-)(65626-52-0)

Safety Data

• Hazardous Substances Data: 65626-52-0(Hazardous Substances Data)

Upstream product

• 163133-86-6 pyrimidin-4-amine 
• 64723-97-3 1,1,1-trifluoroacetone enolate anion 

Relevant articles and documents

Models for Strong Interactions in Proteins and Enzymes. 1. Enhanced Acidities of Principal Biological Hydrogen Donors

The acid dissociation energies of several key biological hydrogen donors are found to fall into a narrow range, ΔHoacid=352-355 kcal/mol.The strong acidities of these donor groups enhance the hydrogen bond strengths involved in the protein α-helix, imidazole enzyme centers and DNA.Specifically, the peptide link is modeled by the dipeptide analogue CH3CO-Ala-OCH3.Its acidity is strengthened, i.e. ΔHoacid is decreased by 8 kcal/mol compared with other amides, due to electrostatic stabilization by the second carbonyl in the peptide -CON-CH(CH3)CO- grouping.The acidity of imidazole is also strengthened by 8 kcal/mol compared with that of the parent molecule, pyrrole, primarily due to resonance stabilization of the ion.Hydrogen donor NH2 groups of adenine and cytosine are modeled by 4-aminopyrimidine, and the acidity of this amine group is strengthened by ring aza substitution.An intrinsic acidity optimized for hydrogen bonding strength therefore emerges as a common property of the diverse hydrogen donors in the protein α-helix, enzymes and DNA.This property may therefore be in part responsible for the natural selection of these molecules as principal biological hydrogen donors.