6563-37-7Relevant academic research and scientific papers
Aspergillus niger catalyzes the synthesis of flavonoids from chalcones
Alarcon, Julio,Alderete, Joel,Escobar, Carlos,Araya, Ramiro,Cespedes, Carlos L.
, p. 160 - 167 (2013/09/12)
Flavonoids, which have many biological activities and have been widely used in nature, can be artificially synthesized. However, regioselective cyclization of chalcones is difficult by chemical methods. In this study, we demonstrated that Aspergillus nige
Production of hydroxlated flavonoids with cytochrome P450 BM3 variant F87V and their antioxidative activities
Kitamura, Emi,Otomatsu, Toshihiko,Maeda, Chiemi,Aoki, Yoko,Ota, Chihiro,Misawa, Norihiko,Shindo, Kazutoshi
, p. 1340 - 1343 (2013/07/26)
A variant of P450 BM3 with an F87V substitution [P450 BM3 (F87V)] is a substrate-promiscuous cytochrome P450 monooxygenase. We investigated the bioconversion of various flavonoids (favanones, chalcone, and isoflavone) by using recombinant Escherichia coli cells, which expressed the gene coding for P450 BM3 (F87V), to give their corresponding hydroxylated products. Potent antioxidative activities were observed in some of the products.
