6563-48-0Relevant academic research and scientific papers
XANTHONE AND FLAVONOL CONSTITUENTS OF SWERTIA HOOKERI
Ghosal, Shibnath,Biswas, Kanika,Jaiswal, Dinesh K.
, p. 123 - 126 (1980)
The whole plant of Swertia hookeri, collected at flowering has been shown to contain two tri- and nine tetraoxygenated free, glucosyloxy, and stearyl ester xanthones and one flavonol stearyl ester.Among these, three are previously unreported in nature and one was known previously only as a synthetic compound.The xanthones are based on 1,3,5-, 1,3,5,8- and 1,3,7,8-oxygenated systems with the middle oxygenation pattern predominating.The two ester compounds appeared only at the flowering stage.Plants collected at the pre-flowering stage gave the corresponding free compounds.The biochemical and biological significance of these findings are appraised.Key Word Index - Swertia hookeri; Gentianaceae; 1-O-stearyl-3,5-dimethoxyxanthone; 3-O-stearyl-3',4',5,7-tetra-O-methylquercetin; 1-hydroxy-3,5-dimethoxyxanthone; tetraoxygenated xanthones; 8-O-β-D-glucosyl-1,3-dihydroxy-5-methoxyxanthones; 8-O-β-D-glucosyl-1,5-dihydroxy-3-methoxyxanthone.
Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity
Wan, Luo-Sheng,Min, Qiu-Xia,Wang, Yong-Long,Yue, Yao-Dong,Chen, Jia-Chun
, p. 1248 - 1253 (2013/08/23)
Ten new xanthone glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC 50 values in the range 126 to 451 μM) displayed more potent inhibitory effects against α-glucosidase activity than the positive control, acarbose (IC50 value of 627 μM).
