65638-95-1

Upstream product

• 70006-59-6 2,2-Diphenyl-1,3-benzodioxol-5-methanol 
• 65638-94-0 2,2-diphenylbenzo(1,3-dioxole)-5-carboxylic acid methyl ester 
• 2051-90-3 Dichlorodiphenylmethane 

Downstream Products

• 717131-89-0 C-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-methylamine 
• 717131-87-8 5-azidomethyl-2,2-diphenyl-benzo[1,3]dioxole 

Relevant academic research and scientific papers

Hydroxytyrosol NO donor derivative, and preparation method and application thereof

The invention discloses a hydroxytyrosol NO donor derivative, and a preparation method and an application thereof. The hydroxytyrosol NO donor derivative is used for preparing hypoglycemic and endothelial protection medicines. As a result of in-vitro and in-vivo pharmacological experiments, the above compound has the following pharmacological activities: (1) active oxygen radical removing activity, (2) NO releasing and vasodilation activity, and (3) glucosidase activity inhibition activity and a certain hypoglycemic effect. As a result of in-vivo pharmacokinetic experiments, the derivative can release NO quickly in body such that NO can reach a relatively high level. The invention also provides the preparation method of the hydroxytyrosol NO donor derivative. A modified derivative can be obtained through 4 steps of organic synthesis. The method has the advantages of easy-to-obtain raw materials, mild reaction conditions, simple reaction process operation, and inexpensive agents. The derivative has significant hypoglycemic and vasodilation effects, and can be used in controlling diabetes and vascular complication thereof. The derivative has a great clinical application value.

Linker-modified quinoline derivatives targeting HIV-1 integrase: Synthesis and biological activity

A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide