6566-38-7Relevant academic research and scientific papers
Enantiomerically Enriched α-Borylzinc Reagents by Nickel-Catalyzed Carbozincation of Vinylboronic Esters
Zhang, Chenlong,Hu, Weipeng,Lovinger, Gabriel J.,Jin, Jing,Chen, Jingjia,Morken, James P.
supporting information, p. 14189 - 14195 (2021/09/11)
In this paper is described a synthesis of enantiomerically enriched, configurationally stable organozinc reagents by catalytic enantioselective carbozincation of a vinylboronic ester. This process furnishes enantiomerically enriched α-borylzinc intermediates that are shown to undergo stereospecific reactions, producing enantioenriched secondary boronic ester products. The properties of the intermediate α-borylzinc reagent are probed and the synthetic utility of the products is demonstrated by application to the synthesis of (-)-aphanorphine and (-)-enterolactone.
Diastereoselective and Enantioselective Conjunctive Cross-Coupling Enabled by Boron Ligand Design
Myhill, Jesse A.,Wilhelmsen, Christopher A.,Zhang, Liang,Morken, James P.
supporting information, p. 15181 - 15185 (2018/11/30)
Enantio- and diastereoselective conjunctive cross-coupling of β-substituted alkenylboron "ate" complexes is studied. Whereas β-substitution shifts the chemoselectivity of the catalytic reaction in favor of the Suzuki-Miyaura product, use of a boronic este
