65685-49-6

Basic information

• Product Name: 5-Methylbenzo[d]isoxazol-3(2H)-one
• Synonyms: 5-Methylbenzo[d]isoxazol-3(2H)-one;5-Methyl-benzo[d]isoxazol-3-ol
• CAS NO: 65685-49-6
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Mol File: 65685-49-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.259±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.86±0.20(Predicted)
• CAS DataBase Reference: 5-Methylbenzo[d]isoxazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylbenzo[d]isoxazol-3(2H)-one(65685-49-6)
• EPA Substance Registry System: 5-Methylbenzo[d]isoxazol-3(2H)-one(65685-49-6)

Safety Data

• Hazardous Substances Data: 65685-49-6(Hazardous Substances Data)

Upstream product

• 61799-77-7 2,N-dihydroxy-5-methylbenzamide 
• 22717-57-3 methyl 6-hydroxy-m-toluate 
• 61799-77-7 2,N-dihydroxy-5-methyl-benzamide 

Downstream Products

• 1299489-82-9 5-bromomethyl-3-(tetrahydro-pyran-2-yloxy)-benzo[d]isoxazole 
• 1299489-59-0 5-methyl-2-trityl-benzoisoxazol-3-one 
• 1299489-77-2 5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-ol 
• 1299489-85-2 [5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yloxy]-acetic acid 
• 1299489-93-2 3-[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yloxy]-propionic acid 
• 1299490-58-6 5-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-ol 
• 1299489-57-8 5-bromomethyl-2-trityl-benzo[d]isoxazol-3-one 
• 1299489-83-0 5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-3-(tetrahydro-pyran-2-yloxy)benzo[d]isoxazole 
• 1299489-95-4 3-[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yloxy]-propionic acid tert-butyl ester 
• 1299490-59-7 5-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-2-trityl-benzo[d]isoxazol-3-one 
• 1299489-86-3 [5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yloxy]-acetic acid ethyl ester 
• 196708-35-7 3-chloro-5-methyl-1,2-benzisoxazole 

Relevant articles and documents

BENZISOXAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful

BENZISOXAZOLES

The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents an integer from 1 to 3; X represents amino, hydroxy, -oxo or -Z-R1; Y is absent when X represents -Z-R1 and -(C=O)-R66 when X represents oxo; Z represents carbonyl, -oxy-carbonyl- or -NR 55-carbonyl-; R1 represents C1-4alkyl, Ar1, Ar1-C1-4a1ky1-, -NR3R4 or -Het1; R2 represents hydrogen, halo, nitro, hydroxycarbonyl-, C1-4alkyloxy or C1-4alkyl; R33 and R4 are each independently selected from hydrogen, Ar33 or C1-4alkyl; R5 represents hydrogen, C1-4alkylcarbonyl- or Ar4-carbonyl-; R6 represents a substituent selected from the group consisting of C1.4alkyl, Ar55, Ar6-C1-4alkyl- or NR7R8; R7 and R8 are each independently selected from hydrogen, Het4 or C1-4alkyl; Het1 represents a heterocycle selected from oxazolyl, isoxazolyl, imidazolyl or pyrazolyl wherein said heterocycle is optionally substituted with one, two or three substituents selected from the group consisting of amino, C1-4alkyl, hydroxy-C1-4alkyl, phenyl, phenyl-C1-4alkyl- and phenyl substituted with one or more halo substituents; Het4 represents a heterocycle selected from oxazolyl or isoxazolyl, wherein said heterocycle is optionally substituted with one or more substituents selected from the group consisting of amino, C1-4alkyl, hydroxy-C1-4alkyl-, phenyl, phenyl-Cl-4alkyl and phenyl substituted with one or more halo substituents; and Ar1, Ar2, Ar3, Ar4, Ar5 or Ar6 each independently represents phenyl optionally substituted one or where possible two or more substituents selected from halo, nitro, C1-4alkyl, hydroxy or C1-4alkyloxy-.

Isoxazole derivatives

An isoxazole compound having the following formula: wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.