65686-95-5

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1-(thiophen-2-yl)ethanamine is utilized as an intermediate in the synthesis of various drugs and pharmaceuticals. Its unique structure and functional groups make it a valuable building block for the development of new medications with improved efficacy and safety profiles.
Used in Chemical Industry:
In the chemical industry, 2,2,2-trifluoro-1-(thiophen-2-yl)ethanamine serves as a key intermediate for the production of agrochemicals and other specialty chemicals. Its reactivity and compatibility with various chemical reactions contribute to the synthesis of a wide range of compounds with diverse applications.
Used in Organic Synthesis:
2,2,2-Trifluoro-1-(thiophen-2-yl)ethanamine has been studied for its potential as a building block in organic synthesis. Its presence in various chemical reactions can lead to the formation of novel compounds with unique properties, expanding the scope of organic chemistry and enabling the development of new materials and products.
Used in Medication Development:
2,2,2-Trifluoro-1-(thiophen-2-yl)ethanamine has been investigated for its pharmacological properties, with potential applications as a medication for various health conditions. Its unique structure and functional groups may contribute to the development of new therapeutic agents with improved efficacy and reduced side effects.

InChI:InChI=1/C6H6F3NS/c7-6(8,9)5(10)4-2-1-3-11-4/h1-3,5H,10H2

Upstream product

• 188290-36-0 thiophene 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 294174-98-4 benzhydryl[2,2,2-trifluoro-1-(thiophen-2-yl)ethyl]amine 

Relevant academic research and scientific papers

Silver-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides: a facile stereoselective synthesis of CF3-substituted heterocycles

An Ag-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides with polar double bonds has been developed for the facile access to trifluoromethylated oxazolines, imidazolines and pyrrolines under mild conditions. The practicality of this chemistry is demonstrated by the gram-scale synthesis of oxazolines with excellent yields and facile transformations of the formed oxazolines to trifluoromethylated β-amino alcohols in quantitative yields.

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal

Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. [(1-Aryl-2,2,2-trifluoro)ethyl]amines or bis[(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields.

BF3-promoted aromatic substitution of N-alkyl α-trifluoromethylated imine: Facile synthesis of 1-aryl-2,2,2-trifluoroethylamines

The aromatic substitution of three representative N-alkyl trifluoromethyl imines 1a-c (R: a, benzyl; b, benzhydryl; c, methyl), obtained from primary alkyl amines and trifluoroacetaldehyde ethyl hemiacetal, was used to investigate the preparation of 1-aryl-2,2,2-trifluoroethylamines. In the presence of BF3·OEt2, the reaction of imine 1 with various aromatic compounds proceeded smoothly at room temperature, giving N-alkyl-1-aryl-2,2,2-trifluoroethylamines in moderate-to-high yields. Moreover, successful regioselective removal of N-benzyl and N-benzhydryl groups was achieved by hydrolysis in hydrochloric acid or by palladium-catalyzed hydrogenolysis.

Friedel-Crafts reaction of N-alkyl trifluoroacetaldehyde imine: Facile synthesis of 1-aryl-2,2,2-trifluoroethylamines

N-Alkyl trifluoroacetaldehyde imines 1a,b (R: a, benzyl; b, diphenylmethyl), prepared from trifluoroacetaldehyde ethyl hemiacetal (TFAE) and primaryl amines, readily reacted with electron-rich heteroarenes, N,N- dimethylaniline and phenols in the presence of BF3. Product analysis showed moderate to high yields of N-alkyl-1-aryl-2,2,2-trifluoroethylamines 2-7. Hydrolysis of representative N-diphenylmethyl amines 5b and 7b, respectively yielded the 1-aryl-2,2,2-trifluoroethylamines 10 and 11.