65695-07-0

Basic information

• Product Name: 2-Benzofurancarboximidamide,N-hydroxy-
• Synonyms: 2-Benzofurancarboximidamide,N-hydroxy-;2-Benzofurancarboximidamide,N-hydroxy-(9CI);2-Benzofurancarboxamide oxime;Brn 0006957;N-Hydroxy-2-benzofurancarboximidamide
• CAS NO: 65695-07-0
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17202
• Product Categories: AMIDINE
• Mol File: 65695-07-0.mol

Chemical Properties

• Boiling Point: 378.1 °C at 760 mmHg
• Flash Point: 182.5 °C
• Appearance: /
• Density: 1.4 g/cm³
• CAS DataBase Reference: 2-Benzofurancarboximidamide,N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzofurancarboximidamide,N-hydroxy-(65695-07-0)
• EPA Substance Registry System: 2-Benzofurancarboximidamide,N-hydroxy-(65695-07-0)

Safety Data

• Hazardous Substances Data: 65695-07-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzofurancarboximidamide, N-hydroxyis used as a potential antitumor agent for its demonstrated cytotoxic effects on cancer cells. Its specific mechanism of action and therapeutic applications are under investigation, but its capacity to target and inhibit tumor growth makes it a valuable subject for further research in medicinal chemistry and drug development.
Used in Cancer Research:
In the field of cancer research, 2-Benzofurancarboximidamide, N-hydroxyis utilized to explore its potential as a new therapeutic agent. Its unique chemical structure and observed antitumor activities are of interest to scientists seeking novel compounds that can effectively combat various types of cancer.

Upstream product

• 41717-32-2 benzofuran-2-carbonitrile 

Relevant articles and documents

Chloro-oxime derivatives as novel small molecule chaperone amplifiers

Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 10 μM).

BENZOFURYL DERIVATIVES AND THEIR USE

The invention is concerned with the use of compounds of general formula (I) wherein R1-R4signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R1and R2t

METHOD OF TREATING DISEASES OF THE CNS

The invention is concerned with the use of compounds of the general formula STR1 wherein R 1-R 4 signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R

Analgesic and antiinflammatory properties of 2-benzofuran amidoximes

2-Benzofuran carboximidamide and various of its substituted derivatives have been tested for analgesic, anti-inflammatory and ulcerigeneous activity. For comparison, the same tests were performed with 2-naphto[2,1-b]furan carboximidamide, some 3-benzopyrancarboximidamides and 2-furan carboximidamide. Most 2-benzofurancarboximidamides show to have interesting analgesic properties. Some of them are also anti-inflammatories. 3-Methyl-5-bromo-2-benzofurancarboximidamide can be compared to aspirin and phenylbutazone as analgesic and anti-inflammatory respectively; no significant ulcerigeneous effect was noted for this compound.