65698-22-8

Usage

Chemical structure

A derivative of indenone with two hydroxyl (-OH) groups at the 2 and 3 positions, and two hydroxyl groups at the 4 and 7 positions.

Physical form

Pale yellow solid

Potential applications

Medicine and pharmaceuticals, as an intermediate in the synthesis of various bioactive compounds.

Usage

Research and development for the synthesis of novel organic compounds and pharmaceutical substances.

Upstream product

• 52428-09-8 4,7-dimethoxyindan-1-one 

Downstream Products

• 100848-76-8 endo-4a,5,8,8a-tetrahydro-1-hydroxy-1-phenyl-5,8-methanobenzindane-4,9-quinone 
• 100848-79-1 endo-4a,5,8,8a-tetrahydro-1-phenyl-5,8-methanobenzindane-4,9-quinone 
• 100848-77-9 4,7-dihydroxy-1-phenylindane 
• 100848-78-0 1-phenylindane-4,7-quinone 
• 100848-75-7 1-hydroxy-1-phenylindane-4,7-quinone 

Relevant academic research and scientific papers

First total synthesis of palmarumycin C6 based on double oxa-michael addition of 1,8-dihydroxynaphthalene to 3-bromo-1-indenone

Synthetic studies on palmarumycin C6 with a naphthyl acetal at the C-3 position in 4,7-dihydroxy-1-indanone as a lower homologue of spirobisnaphthalenes are described herein. We investigated three approaches: 1) Nazarov cyclization of benzoylketene acetal, 2) intramolecular Friedel-Crafts acylation of naphtho[1,8-de]-1,3-dioxin-2-aryl-2-acetic acid chloride, and 3) double oxa-Michael addition of 1,8-dihydroxynaphthalene to 3-bromo-1-indenone. The last approach successfully afforded the natural product after the removal of acetates that serve as protecting groups for phenolic hydroxyls under acidic conditions.

POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL POLYMER FILM

PROBLEM TO BE SOLVED: To provide a polymerizable liquid crystal compound that reduces defects in the optical functions of products made from a liquid crystal polymer film, and reduces the material costs of the products, and also reduces the thickness of the products. SOLUTION: The present invention provides a polymerizable liquid crystal compound represented by formula (1) (A1 is 1,4-phenylene, 1,4-cyclohexylene, 1,4-cyclohexenylene, pyridine-2,5-diyl, 1,3-dioxane-2,5-diyl or naphthalene-2,6-diyl; Z1 is a linking group; m and n independently represent an integer of 0-5; 1≤m+n≤8; X1 is a C1-5 alkylene substituted/unsubstituted with a hetero atom; at least one of R1's is a polymerizable functional group). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Benzoquinones and Related Compounds. Part 5. Nuclear Magnetic Resonance Study of the Conformation in Solution of Some Diels-Alder Adducts between 1,4-Benzoquinones and Cyclopentadiene

The Diels-Alder reaction of cyclopentadiene with the 5,6-double bond of benzyl-, α-hydroxybenzyl-, and α-acetoxybenzyl-1,4-benzoquinone, and of 1-hydroxy-1-phenyl-, 1-phenyl-, and 1-hydroxy-indan-4,7-quinone gives in each case a pair of diastereoisomeric endo adducts.For those which carry a phenyl group, the chemical shift of one of the norbornene olefinic protons in one member of each pair is significantly different from that of the corresponding proton in the other member.The conformational significance of this effect is discussed.Proton longitudinal relaxation and nuclear Overhauser relaxation techniques are used to show that the cyclopentadiene endo monoadducts of 1,4-benzoquinone and α-hydroxybenzyl-1,4-benzoquinone prefer to adopt an 'open' rather than a 'closed' conformation.