65705-40-0Relevant academic research and scientific papers
Synthesis of New Condensed Pyrimidine Systems: Reactions of Heterocyclic Amines with Acetylenic Esters
Sahu, J. K.,Dehuri, S. N.,Naik, S.,Nayak, A.
, p. 117 - 120 (2007/10/02)
Several hitherto unreported 1,3,4-oxa/thiadiazolopyrimidin-7-ones (1 and 2) and thiazolopyrimidin-7-ones (3) have been synthesised by the reaction of 2-amino-1,3,4-oxa/thiadiazoles and 2-amino-4-arylthiazoles respectively with ethyl phenylpropiolate.The reaction of these amines with diethyl acetylenedicarboxylate furnishes the 7-oxo-5-carbethoxy derivatives (8-10).A similar reaction of 2-aminobenzothiazole with diethyl acetylenedicarboxylate affords 4-carbethoxypyrimidobenzothiazol-2(H)-one (7).To assign the structures of the 7-oxo derivatives the isomeric 5-oxo-7-carbethoxy derivatives (14) have also been synthesised by an unambiguous route.
Pharmaceutical compositions and methods of using thiadiazolo pyrimidinone compounds
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, (2008/06/13)
Substituted 7H-thiazolo- and 7H-thiadiazolo-pyrimidine-7-ones compounds and the drug composition containing same. The compounds are immunostimulants for mammals. A process of making these compounds and of using the drug composition.
