65709-27-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Methoxy-phenyl)-piperazine is used as a therapeutic agent for its potential role in the treatment of psychiatric disorders such as depression, anxiety, and schizophrenia. Its agonistic effects on serotonin receptors contribute to its psychotropic properties, making it a subject of interest in pharmaceutical research and development.
Used in Research Applications:
In the scientific community, 2-(2-Methoxy-phenyl)-piperazine serves as a research chemical, aiding in the study of serotonin receptor mechanisms and their influence on mood and behavior. This helps researchers better understand the pathways involved in mental health conditions and develop more effective treatments.

InChI:InChI=1/C11H16N2O/c1-14-11-5-3-2-4-9(11)10-8-12-6-7-13-10/h2-5,10,12-13H,6-8H2,1H3

Upstream product

• 578-57-4 2-bromoanisole 
• 66644-69-7 ethyl (2-methoxyphenyl)(oxo)acetate 

Relevant academic research and scientific papers

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

2-Arylpiperazine derivatives and the preparation thereof

A process is provided for preparing 2-arylpiperazine derivatives and more particularly, 2-phenylpiperazine derivatives of the formula STR1 wherein R represents a group selected from the group consisting of a halogen atom, a lower alkyl group (having carbon atoms of 1 to about 8, preferably 1 to 4), a lower alkoxy group (having carbon atoms of 1 to about 8, preferably 1 to 4), a nitro group, a cyano group, a benzyloxy group, a hydroxy group and when n is 2 R is a methylenedioxy group, and n represents 1, 2 or 3.