65709-31-1

Usage

Uses

Used in Pharmaceutical Industry:
2-p-tolylpiperazine is used as a building block in the synthesis of bioactive molecules for the nervous system, as its derivatives can potentially influence dopamine receptors.
Used in Chemical Research:
2-p-tolylpiperazine is used as a research compound in organic synthesis, contributing to the development of new chemical entities and understanding of chemical reactions.

Upstream product

• 108030-80-4 2-(4-methylphenyl)pyrazine 
• 1421004-98-9 C₂₅H₂₈N₂ 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 922524-99-0 2-p-tolylpyrazine 1-oxide 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

B(C6F5)3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.

A simple one-pot method for the mercuric oxide mediated synthesis of piperazines via oxidative diamination of olefins

Mercuric oxide mediated one-pot synthesis of substituted piperazines via oxidative diamination of olefins with N-protected ethylene diamine has been reported. Among the various conditions tried, mercuric(II)oxide/tetrafluoroboric acid gave good to excellent yields of the desired products. A series of piperazines have been synthesized and characterized by NMR and mass spectroscopy methods.

Use of N-oxide compounds in coupling reactions

Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3

Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides

New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield

2-Arylpiperazine derivatives and the preparation thereof

A process is provided for preparing 2-arylpiperazine derivatives and more particularly, 2-phenylpiperazine derivatives of the formula STR1 wherein R represents a group selected from the group consisting of a halogen atom, a lower alkyl group (having carbon atoms of 1 to about 8, preferably 1 to 4), a lower alkoxy group (having carbon atoms of 1 to about 8, preferably 1 to 4), a nitro group, a cyano group, a benzyloxy group, a hydroxy group and when n is 2 R is a methylenedioxy group, and n represents 1, 2 or 3.