65709-31-1

Basic information

• Product Name: 2-p-tolylpiperazine
• Synonyms: 2-(4-Methylphenyl)-piperazine 2HCl
• CAS NO: 65709-31-1
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.26
• Mol File: 65709-31-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 88.7-90.3 °C
• Boiling Point: 308.9±32.0 °C(Predicted)
• Appearance: /
• Density: 0.984±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.87±0.40(Predicted)
• CAS DataBase Reference: 2-p-tolylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-p-tolylpiperazine(65709-31-1)
• EPA Substance Registry System: 2-p-tolylpiperazine(65709-31-1)

Safety Data

• Hazardous Substances Data: 65709-31-1(Hazardous Substances Data)

Usage

General Description

2-p-tolylpiperazine, also known scientifically as 1-(4-Methylphenyl)piperazine, is a chemical compound featuring in various pharmacological applications. Its structure consists of a benzene ring substituted by both a methyl group and a piperazine at different positions. Primarily, it functions as a building block in organic synthesis and overall chemical research. Additionally, it can serve as an intermediate in the production of bioactive molecules. Specifically, it plays a vital role in the development of drugs used for the nervous system, with its derivatives potentially influencing dopamine receptors. Given its broad usage, this chemical necessitates appropriate safeguards during handling and usage to mitigate any potential hazards. The health effects or risks associated with this chemical depend on factors like exposure levels, the duration of exposure, and individual susceptibility.

Upstream product

• 108030-80-4 2-(4-methylphenyl)pyrazine 
• 1421004-98-9 C₂₅H₂₈N₂ 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 922524-99-0 2-p-tolylpyrazine 1-oxide 

Relevant articles and documents

B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

B(C6F5)3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.

Use of N-oxide compounds in coupling reactions

Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3

2-Arylpiperazine derivatives and the preparation thereof

A process is provided for preparing 2-arylpiperazine derivatives and more particularly, 2-phenylpiperazine derivatives of the formula STR1 wherein R represents a group selected from the group consisting of a halogen atom, a lower alkyl group (having carbon atoms of 1 to about 8, preferably 1 to 4), a lower alkoxy group (having carbon atoms of 1 to about 8, preferably 1 to 4), a nitro group, a cyano group, a benzyloxy group, a hydroxy group and when n is 2 R is a methylenedioxy group, and n represents 1, 2 or 3.