65715-21-1

Usage

Uses

Used in Pharmaceutical Industry:
Benzofuran, 3-(trifluoromethyl)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and selectivity. It has been studied for its potential as a central nervous system stimulant, offering potential benefits in the treatment of neurological disorders and cognitive enhancement.
Used in Agrochemical Industry:
In the agrochemical industry, Benzofuran, 3-(trifluoromethyl)serves as a building block for the synthesis of various pesticides. Its unique chemical properties enable the development of novel agrochemicals with enhanced pest control capabilities and reduced environmental impact.
Used in Neuroprotection and Neurodegenerative Disease Research:
Benzofuran, 3-(trifluoromethyl)has been studied for its potential neuroprotective effects, making it a promising candidate for the development of therapeutic agents targeting neurodegenerative diseases. Its ability to modulate various signaling pathways and protect neurons from damage offers hope for the treatment of conditions such as Alzheimer's, Parkinson's, and multiple sclerosis.
Used in the Development of New Therapeutic Agents:
Ongoing research is exploring the potential uses of Benzofuran, 3-(trifluoromethyl)in the development of new therapeutic agents. Its unique structure and biological properties provide a foundation for the design of innovative drugs with improved pharmacokinetics, selectivity, and efficacy in various therapeutic areas, including oncology, cardiovascular diseases, and inflammatory conditions.

Upstream product

• 271-89-6 1-benzofurane 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 59214-70-9 3-bromobenzofuran 
• 2314-97-8 iodotrifluoromethane 

Relevant academic research and scientific papers

Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex

While several trifluoromethylation reactions involving the electrochemical generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochemical reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.

Studies on Organic Fluorine Compounds. Part 27. Abnormal Reactions in the Trifluoromethylation of Aromatic Compounds with Trifluoromethyl Iodide and Copper Powder

Reaction of 3-bromobenzofuran with trifluoromethyl iodide and copper powder in pyridine gave 2-(trifluoromethyl)-, 2- and 3-(pentafluoroethyl)-, and 2,3-bis(trifluoromethyl)-benzofuran, as well as the expected product, 3-(trifluoromethyl)benzofuran.Bromoanisole also gave (trifluoromethyl)anisole and (pentafluoroethyl)anisole, but introduction of the perfluoroalkyl group occurred at the position originally occupied by the bromine.Formation of pentafluoroethyl compounds is explained by decomposition of trifluoromethylcopper to cuprous fluoride and difluorocarbene, which can then react with a further molecule of trifluoromethylcopper to form pentafluoroethylcopper.This then reacts with aryl halide to give pentafluoroethyl compounds.Perfluoroalkylcopper is thermally cleaved to perfluoroalkyl radical, which then reacts with pyridine to give perfluoroalkylpyridines.This mechanism must be involved in the formation of 2,3-bis(trifluoromethyl)benzofuran.Introduction of a perfluoroalkyl group to the position originally unoccupied with halogen might be due to the rather localized double bond in benzofuran.