65715-48-2Relevant academic research and scientific papers
Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)–WDR5 interaction
Li, Dong-Dong,Wang, Zhi-Hui,Chen, Wei-Lin,Xie, Yi-Yue,You, Qi-Dong,Guo, Xiao-Ke
, p. 6109 - 6118 (2016)
WDR5 is an essential protein for enzymatic activity of MLL1. Targeting the protein–protein interaction (PPI) between MLL1 and WDR5 represents a new potential therapeutic strategy for MLL leukemia. Based on the structure of reported inhibitor WDR5-0103, a
BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS
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Page/Page column 50, (2008/06/13)
A compound having formula (I): wherein: R, A, R1 and R2, are as defined in the specification, and pharmaceutical formulas thereof, and methods of use thereof
