65734-58-9

Upstream product

• 269064-59-7 (S)-tert-butyl (1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)carbamate 
• 56-41-7 L-alanin 
• 104-94-9 4-methoxy-aniline 
• 58178-16-8 benzyl (S)-(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)carbamate 

Downstream Products

• 871579-20-3 (Z)-2-acetylamino-N-[(S)-N-(4-methoxyphenyl)-2-propionamido]-3-(1-naphthyl)-2-propenamide 
• 1325238-12-7 4-[1-(4-methoxyphenylcarbamoyl)ethylamino]pent-4-enoic acid 
• 1325238-13-8 4-oxopent-2-enoic acid [1-(4-methoxyphenylcarbamoyl)ethyl]amide 
• 1325238-14-9 N₁-benzyloxy-N₂-[1-(4-methoxyphenylcarbamoyl)ethyl]succinamide 
• 1325238-16-1 3-[1-(4-methoxyphenylcarbamoyl)ethylcarbamoyl]acrylic acid 

Relevant academic research and scientific papers

Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature

Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].

N-SUBSTITUTED PYRAZOLO [3,4-D] PYRIMIDINE KETONE COMPOUND, AND PREPARATION PROCESS AND USE THEREOF

Disclosed are an N-substituted pyrazolo[3,4-d]pyrimidine ketone compound of formula (I), and a preparation process and use thereof as a phosphodiesterase IX (PDEIX) inhibitor: wherein R′ is selected from isopropyl, cyclopentyl, cyclohexyl, isobutyl, and o

Design and synthesis of small molecules based on a substructural analysis of the histone deacetylase inhibitors TSA and SAHA

Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors.

Proline-based dipeptides with two amide units as organocatalyst for the asymmetric aldol reaction of cyclohexanone with aldehydes

A series of proline-based dipeptide organocatalysts with two amide units (1-16) have been developed and evaluated in the direct catalytic asymmetric aldol reactions of aldehydes with cyclohexanone. These catalysts showed good solubility in organic solvents compared with their corresponding carboxyl terminal dipeptides. The robust amide bond formation allowed structural modifications and fine tuning of catalyst properties by varying the stereo and electronic effects of the terminal amide to affect the ability of hydrogen bonding formation between the catalysts and the substrates. The reactions proceeded smoothly in high yields (up to 99%), enantioselectivities (up to 98% ee) and anti-diastereoselectivities (up to 99:1) in the presence of bifunctional organocatalyst 4 under the optimal reaction conditions.

Electron transfer-initiated asymmetric photocyclization of chiral auxiliary-substituted N-acyl-α-dehydro(1-naphthyl)alaninamides to the corresponding 3,4-dihydrobenzo[f]quinolinone derivatives

Photoinduced electron transfer reactions of the title N-acyl-α- dehydronaphthylalaninamides [(Z)-1] with (S)-1-phenylethylamino and (S)-alaninamide auxiliary groups in methanol containing a tertiary amine were shown to form (R,S)- and (S,S)-3,4-dihydroben

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists.