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Usage

Uses

Used in Pharmaceutical Industry:
2-[(ADAMANTAN-1-YLMETHYL)-AMINO]-ETHANOL is used as a medication for the treatment of Alzheimer's disease. It functions by selectively blocking the receptors for the neurotransmitter glutamate, which is believed to contribute to the disease's progression. This action helps to alleviate the symptoms of Alzheimer's and improve cognitive function in affected individuals.
As a treatment for Alzheimer's disease, memantine is generally well-tolerated with minimal side effects, offering a beneficial option for managing the cognitive decline associated with this condition. Its selective targeting of specific receptors also contributes to its effectiveness and safety profile, distinguishing it as a valuable component in the therapeutic arsenal against Alzheimer's.

InChI:InChI=1/C13H23NO/c15-2-1-14-9-13-6-10-3-11(7-13)5-12(4-10)8-13/h10-12,14-15H,1-9H2

Upstream product

• 75-21-8 oxirane 
• 17768-41-1 adamantylmethylamine 
• 2094-72-6 1-Adamantanecarbonyl chloride 
• 770-71-8 1-adamantanemethanol 
• 51849-10-6 1-adamantane methyl iodide 
• 141-43-5 ethanolamine 
• 78743-65-4 2-<<(1-adamantyl)carbonyl>amino>ethanol 

Relevant academic research and scientific papers

Novel antitumor adamantane-azole gold(I) complexes as potential inhibitors of thioredoxin reductase

Gold complexes that could act as antitumor agents have attracted great attention. Heterocyclic compounds and their metal complexes display a broad spectrum of pharmacological properties. The present study reports the preparation and characterization of fo

Heterocyclic Deformations from Molecular Enlargement

The ease of distortion of saturated nitrogen heterocycles has been examined by progressively increasing the bulk of the substituent at nitrogen.The heterocycles included the pharmacophoric piperidine and morpholine six-membered rings, as well as the five-membered oxazolidine ring.Response to increased bulk of substitution was intended to be a crude model for distortions within the drug-receptor complex.Substitution at nitrogen included methyl, (1-adamantyl)methyl, and 6-substituted β-cyclodextrin within a tetrahedral series, and acetyl and (1-adamantyl)carbonyl within a trigonal series.With methyl and acetyl serving as standards for the undistorted rings, we have found that the NCH2CH2X dihedral angle within all three heterocycles is decreased anly by about 1 deg on introduction of adamantyl groups.In agreement with this flattening distortion, the barrier to ring reversal of the piperidine is decreased by 1.4 kcal/mol on replacement of N-methyl by N-adamantylmethyl.The β-cyclodextrin ring imposes a much more severe distortion, as this same dihedral angle in the piperidine and morpholine rings decreases 5-6 deg.The barrier to rotation about the amide bond decreases 5-6 kcal/mol in all three heterocycles on going from acetyl to adamantylcarbonyl.These studies show that the response of these heterocycles to incresed steric bulk of N substitution is a flatter and hence more flexible ring.

DERIVATIVES OF ADAMANTANE. I. 2-HYDROXYETHYLAMINO DERIVATIVES OF ADAMANTANE

The reaction of 1-bromoadamantane with hydroxyalkylamines leads to the preferential formation of 1-(aminoalkoxy)adamantanes.The 2-hydroxyethylamino derivatives of the adamantane series were obtained by the reaction of ethylene oxide with the corresponding amines.