657389-50-9

Upstream product

• 843664-51-7 (4S,5S)-4((S)-(but-3-en-2-yl)-2-(4-methoxyphenyl))-5-methyl-1,3-dioxane 
• 106357-24-8 (3S,4S,5S)-6-(tert-butyldiphenylsiloxy)-4-hydroxy-3,5-dimethylhexan-1-ene 

Downstream Products

• 1209497-74-4 C₁₆H₂₂O₃ 
• 201854-74-2 (E)-(4S,5R,6R,7R)-5-(4-Methoxy-benzyloxy)-4,6-dimethyl-7-triethylsilanyloxy-deca-2,9-dienoic acid ethyl ester 
• 201854-75-3 (E)-(4S,5R,6R,7R)-5-(4-Methoxy-benzyloxy)-4,6-dimethyl-7-triethylsilanyloxy-deca-2,9-dien-1-ol 
• 201854-72-0 Benzoic acid (2S,3R,4S,5R)-5-hydroxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-oct-7-enyl ester 
• 201854-73-1 (2S,3R,4R,5R)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-5-triethylsilanyloxy-oct-7-en-1-ol 
• 201854-71-9 Benzoic acid (2S,3R,4R)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-pentyl ester 
• 201854-68-4 1-[6-allyl-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydropyran-2-yl]-ethane-1,2-diol 
• 201854-70-8 Benzoic acid (2S,3S,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-enyl ester 

Relevant academic research and scientific papers

Synthesis of C11-desmethoxy soraphen A1α: A natural product analogue that inhibits acetyl-CoA carboxylase

A synthesis of C11-desmethoxy soraphen A1α is described that proceeds in just 14 steps from readily available starting materials. This natural product analogue was identified as a target of interest in a program aimed at identifying novel natural product-inspired inhibitors of acetyl-CoA carboxylase (ACC) as potential anticancer therapeutics. While describing the most efficient synthesis of a soraphen A1α analogue (total syntheses of the natural product have been reported that proceed in 25 to ≥40 linear steps), we also present data supporting the conclusion that C11-heteroatom functionality is a beneficial but unnecessary structural characteristic of soraphen A1α analogues for inhibiting ACC.

Synthetic studies towards phorboxazole A. A concise stereoselective synthesis of the C20-C26 pentasubstituted oxane ring unit

A stereoselective synthesis of the 2,6-cis oxane unit, accommodating five contiguous asymmetric centres, found in the novel marine natural product phorboxazole A 1, is described.