657390-58-4Relevant academic research and scientific papers
Synthesis and biological activity of novel oxazolidinones
Das, Biswajit,Rajarao,Rudra, Sonali,Yadav, Ajay,Ray, Abhijit,Pandya, Manisha,Rattan, Ashok,Mehta, Anita
scheme or table, p. 6424 - 6428 (2010/05/02)
A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results.
NOVEL OXAZOLIDINONE DERIVATIVES
-
Page/Page column 23, (2010/11/29)
The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodr
Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents
Takhi, Mohamed,Singh, Gurpreet,Murugan,Thaplyyal, Nirvesh,Maitra, Soma,Bhaskarreddy,Amarnath,Mallik, Arundhuti,Harisudan,Trivedi, Ravi Kumar,Sreenivas,Selvakumar,Iqbal, Javed
scheme or table, p. 5150 - 5155 (2009/05/26)
Novel oxazolidinone antibacterials bearing a variety of 3-indolylglyoxamide substituents have been explored in an effort to improve the spectrum and potency of this class of agents. A subclass of this series was also made with the diversity at C-5 terminus. These derivatives have been screened against a panel of clinically relevant Gram-positive pathogens and fastidious Gram-negative organisms. Several analogs in this series were identified with in vitro activity superior to linezolid (MIC = 0.25-2 μg/mL). Compounds 10a, 10c, 10e and 10f displayed activity against linezolid resistant Gram-positive organisms (MIC = 2-4 μg/mL). Selected oxazolidinones were evaluated for in vivo efficacy against a mouse systemic infection model.
