657393-38-9

Upstream product

• 657393-37-8 (1S,2S)-1-(3,4,5-trimethoxyphenyl)propane-1,2-diol 
• 20675-95-0 (E)-2,6,-dimethoxy-4-(prop-1-en-1-yl)phenol 
• 487-12-7 isoelemicin 
• 6627-88-9 4-allyl-2,6-dimethoxyphenol 

Downstream Products

• 657393-39-0 toluene-4-sulfonic acid (1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester 
• 658706-64-0 (8R)-oxo-surinamensin 
• 1027821-84-6 4-[(1R,2R)-2-Hydroxy-1-methyl-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-3,5-dimethoxy-benzaldehyde 
• 658706-47-9 (1R,2R)-2-[2,6-dimethoxy-4-((E)-prop-1-enyl)phenoxy]-1-(3,4,5-trimethoxyphenyl)propan-1-ol 
• 657393-30-1 (+)-(8R)-(2,6-dimethoxy-4-propenylphenoxy)-1-(3,4,5-trimethoxyphenyl)propan-1-one 

Relevant academic research and scientific papers

Selective oxidation of benzylic or allylic hydroxyl group of sec-1,2-diols

A mild and efficient method to selectively oxidize chiral sec-1,2-diols has been developed, which demonstrates that 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ) can selectively oxidize benzylic or allylic hydroxyl group of sec-1,2-diols under ultrasound wave promotion. The configuration of the adjacent chiral center is retained.

The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers.

A general asymmetric route to both enantiomers of polysphorin has been developed. The route utilizes polymer-supported reagents, catalysts and scavengers to minimise the need for aqueous work-up and chromatography. This includes application of a method to scavenge 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and a "catch-and-release" procedure to extract the resultant diol following Sharpless asymmetric dihydroxylation. A novel enzymatic selective protection and investigations of a new asymmetric dihydroxylation using microencapsulated osmium tetroxide were also investigated during the course of this study.