657394-58-6

Upstream product

• 591-51-5 phenyllithium 
• 594854-56-5 (R)-3-((tert-butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethylpropanamide 
• 10488-87-6 ethyl 2-benzoylpropionate 
• 1309881-89-7 C₃₆H₅₆BrNO₄SSi₂ 
• 1309881-88-6 C₂₄H₂₈BrNO₄S 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1309881-44-4 (S)-(-)-(Z)-4-[4-acetyl-1-(4-bromobenzenesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-2-methyl-3-phenylpent-3-enoic acid ethyl ester 
• 105859-44-7 methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate 

Downstream Products

• 155189-76-7 (R)-3-hydroxy-2-methyl-1-phenylpropan-1-one 
• 16735-22-1 (S)-3-hydroxy-2-methyl-1-phenylpropan-1-one 

Relevant academic research and scientific papers

Rhodium-catalyzed asymmetric formal olefination or cycloaddition: 1,3-dicarbonyl compounds reacting with 1,6-diynes or 1,6-enynes

A cationic rhodium(I) complex catalyzes the title reaction of 1,6-diynes through a [2+2+2] cycloaddition and subsequent electrocyclic ring opening (see scheme; cod=1,5-cyclooctadiene, H8-binap=2,2′- bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1, 1′-binaphthyl). The asymmetric intramolecular [2+2+2] cycloaddition of 1,3-dicarbonyl compounds with 1,6-enynes was also accomplished. Copyright

Lewis acid-catalyzed asymmetric hydroxymethylation of silicon enolates in aqueous media

Asymmetric hydroxymethylation of silicon enolates with formaldehyde in aqueous media has been achieved using praseodymium triflate and a chiral crown ether. Formaldehyde aqueous solution can be directly used for the reactions, and a water/THF mixture was found to be the best solvent system. This is the first example of catalytic asymmetric hydroxymethylation of silicon enolates.