657424-07-2Relevant academic research and scientific papers
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
-
Paragraph 00927, (2017/08/01)
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Phase transfer catalyzed enantioselective strecker reactions of α-amido sulfones with cyanohydrins
Herrera, Raquel P.,Sgarzani, Valentina,Bernardi, Luca,Fini, Francesco,Pettersen, Daniel,Ricci, Alfredo
, p. 9869 - 9872 (2007/10/03)
A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of α-amino nitriles from α-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed
NEW COMPOUNDS
-
Page/Page column 56, (2010/11/30)
The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
A convenient synthesis of N-boc-protected α-aminonitriles from α-amidosulfones
Banphavichit, Vorawit,Chaleawlertumpon, Saowaluk,Bhanthumnavin, Worawan,Vilaivan, Tirayut
, p. 3147 - 3160 (2007/10/03)
Synthesis of N-Boc-protected α-aminonitriles starting from N-Boc-protected α-aminosulfones is described. Treatment of the sulfone with two equivalents of potassium cyanide in 2-propanol or dichloromethane- H2O under phase transfer condition affords crystalline N-Boc-protected α-aminonitriles in good yield. Hydrolysis of the aminonitriles provides a convenient access to racemic α-amino acids.
