65751-83-9Relevant academic research and scientific papers
Isoquinolines and anti-depressants containing them
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, (2008/06/13)
Isoquinolines of the formula STR1 wherein R1 is H or alkyl of 1 - 4 carbon atoms, R2 is H and R3 is OH or R2 and R3 collectively are a C--C bond, and physiologically acceptable acid addition salts thereof have anti-depressant activity and can be prepared by solvolyzing or hydrogenolyzing a compound of the formula STR2 or an acid addition salt thereof, wherein R4 is R1 or R6, R5 is OR7 or, when R4 is R6, R3 ; R6 and R7 are radicals which can be split off solvolytically or hydrogenolytically and R1 and R2 are as above; and the optional step of dehydrating a resulting carbinol (R2 is H, R3 is OH) and/or treating a resulting compound (R1 is H) with a N-alkylating agent and/or converting a resulting base to a physiologically acceptable acid addition salt by treatment with and acid.
