65754-01-0Relevant academic research and scientific papers
Catalytic hydrogenation on Raney nickel of estra-1,3,5(10),8,14-pentaenes with sterically accessible double bonds
Morozkina,Nikolaev,Selivanov,Ushakov,Shavva
, p. 675 - 680 (2008)
The catalytic hydrogenation of estra-1,3,5(10),8,14-pentaenes with sterically accessible double bonds in the presence of Raney nickel in 2-propanol at elevated pressure and at heating to 110-120°C resulted in prevailing formation of estrogens 8α-analogs alongside a considerable quantity of estra-5,7,9-trienes. Although the hydrogenation at 45-60°C provided a higher yield of estrogens 8α-analogs, the synthesis of steroids of this group gave better results at hydrogenation in a high purity benzene.
