65762-70-1Relevant academic research and scientific papers
A Convenient Synthesis of Apogalanthamine Analogues as α-Adrenergic Blocking Agents using Zerovalent Nickel
Kihara, Masaru,Itoh, Joji,Iguchi, Seiichiro,Imakura, Yasuhiro,Kobayashi, Shigeru
, p. 157 - 177 (2007/10/02)
The apogalanthamine analogues, 5,6,7,8-tetrahydrodibenzazocine (2) and its N-methyl and N-acetyl derivatives (1 and 3), and the methoxy derivatives (4, 5 and 9) of (1) were obtained in good yields by cyclization of the corresponding halogeno-N-benzyl-β-phenethylamines (10a, 11a-d, 12a,b and 13a-c) using stoichiometric amounts of zerovalent nickel generated in situ and potassium iodide.
