65780-83-8Relevant academic research and scientific papers
N-Heterocyclic Carbene Ligand-Controlled Regioselectivity for Nickel-Catalyzed Hydroarylation of Vinylarenes with Benzothiazoles
Li, Rui-Peng,Shen, Zheng-Wang,Wu, Qin-Jia,Zhang, Jie,Sun, Hong-Mei
supporting information, p. 5055 - 5058 (2019/07/03)
A facile regioselective switch for nickel-catalyzed hydroarylation of vinylarenes with benzothiazoles has been developed, which relies on the simple structural variation of novel Ni(II) complexes of the type Ni(NHC)[P(OR)3]Br2. Using magnesium turnings as the reductant, Ni(IMes)[P(OEt)3]Br2 afforded branched products, while Ni(IPr?OMe)[P(OEt)3]Br2 created steric demand to afford linear products. This work also provides a rare example of the rational design of heteroleptic Ni(II) complexes that display the required air stability, reactivity, and regioselectivity via synergism between NHC and phosphite ligands.
Method for synthesizing 1,2-bibenzyl compound
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Paragraph 0028, (2018/06/16)
The invention discloses a method for synthesizing a 1,2-bibenzyl compound. According to the method, a nickelous (II) complex with the molecular formula being Ni[P(OEt)3][(RNCHCHNR)C]Br2 serves as a catalyst, wherein R is 2,6-diphenyl methyl-4-methoxyphenyl), and in the presence of metal magnesium, the 1,2-bibenzyl compound is synthesized through a cross-coupling reaction of benzo-(hetero)arene anda styrene compound. According to the method, the nickelous (II) complex with air stability serves as the catalyst for the first time, so that direct use of sensitive and dangerous metal compounds andzero-valent nickel (0) complexes is avoided; under mild reaction conditions, a zero-valent nickel (0) active center is formed in situ through the action of the metal magnesium, so that the cross-coupling reaction between the benzo-(hetero)arene and the styrene compound is achieved, and a novel method is provide for synthesis of the 1,2-bibenzyl compound.
Site-Selective and Stereoselective C(sp3)-H Borylation of Alkyl Side Chains of 1,3-Azoles with a Silica-Supported Monophosphine-Iridium Catalyst
Murakami, Ryo,Iwai, Tomohiro,Sawamura, Masaya
, p. 1187 - 1192 (2016/05/10)
Site-selective and stereoselective C(sp3)-H borylation of alkyl side chains of 1,3-azoles with bis(pinacolato)diboron was effectively catalyzed by a silica-supported monophosphine-iridium catalyst. The borylation occurred under relatively mild conditions (2 mol% Ir, 50-90 °C), affording the corresponding primary and secondary alkylboronates. This system was applicable to a variety of 1,3-(benzo)azoles such as thiazoles, oxazoles, and imidazoles.
