65795-73-5Relevant academic research and scientific papers
Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists
Ahn, Ho-Sam,Arik, Leyla,Boykow, George,Burnett, Duane A.,Caplen, Mary Ann,Czarniecki, Michael,Domalski, Martin S.,Foster, Carolyn,Manna, Mahua,Stamford, Andrew W.,Wu, Yusheng
, p. 2073 - 2078 (2007/10/03)
A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor. Analogs were prepared to study the structure-activity relationships of substitution at the N1, N3, and N7 positions of the heterocycle. Compounds 4e and 4f have been identified with IC50's of 56 and 52 nM, respectively.
