65797-28-6Relevant academic research and scientific papers
Preparation method of large-steric-hindrance alkyl substituted phosphite diester
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Paragraph 0076-0079, (2020/04/06)
The invention discloses a preparation method of large-steric-hindrance alkyl substituted phosphite diester, and relates to a novel method for preparing the large-steric-hindrance alkyl substituted phosphite diester compound which is difficult to synthesiz
Efficient synthesis of α-substituted ethylphosphonates via CuH-catalyzed conjugate reduction of terminal alkenylphosphonate
Zhang, Li,Fang, Yewen,Jin, Xiaoping,Guo, Ting,Li, Ruifeng,Li, Yan,Li, Xie,Yang, Yi,Yuan, Meijuan,Tian, Zongming
supporting information, p. 4538 - 4541 (2017/11/03)
An unprecedented approach toward synthesis of α-substituted ethylphosphonates based on CuH-catalyzed conjugate reduction of vinylphosphonates has been successfully developed. This protocol features mild conditions, broad substrate scope, good functional group compatibility, high overall efficiencies, and easy gram-scale synthesis. The Cu-catalyzed reduction takes place in a highly selective manner on the phosphono substituted C[dbnd]C bond in the case of the reaction of alkenylphosphonates bearing both phosphono and alkyl or aryl substituted alkene moieties. Furthermore, the result of competitive reaction indicates that the Cu-catalyzed conjugate reduction of vinylphosphonate is more challenging and reproducible than the corresponding acrylate's reaction.
Method for synthesizing alpha-aryl ethyl phosphonate
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Paragraph 0025; 0026; 0027, (2016/11/24)
The invention discloses a method for synthesizing alpha-aryl ethyl phosphonate.The method comprises the following steps that alpha-aryl vinyl phosphonate, potassium phosphate and o-nitro-benzenesulfonyl hydrazide are added into a reactor; after vacuumizing is conducted, N2 is introduced to remove oxygen; under the protection of N2, anhydrous acetonitrile is added, and stirring is conducted for 5-10 h at room temperature; after the reaction is finished, water is added into a reaction mixture for dilution, extraction is conducted with ethyl acetate, drying is conducted with sodium sulphate anhydrous, mixed liquor of petroleum ether and ethyl acetate serves as eluent, column chromatography isolation is conducted, distillation is conducted finally, and alpha-aryl ethyl phosphonate is obtained.According to the method for synthesizing alpha-aryl ethyl phosphonate, transition metal does not participate, the substrate universality is good, the compatibility of a functional group is high, the reaction condition is mild, the reaction efficiency is high, and operation is safe, easy and convenient.
Metal-free diimide reduction of alkenylphosphonates: simple and efficient protocol for the synthesis of α-substituted ethylphosphonates
Fang, Yewen,Yuan, Meijuan,Jin, Xiaoping,Zhang, Li,Li, Ruifeng,Yang, Shaoshuai,Fang, Mei
supporting information, p. 1368 - 1371 (2018/03/23)
A simple and straightforward method for the synthesis of α-substituted ethylphosphonates via diimide reduction strategy is described. With K3PO4 or Na2CO3 as the basic additive, a range of terminal alkenylphosph
Hiyama reactions of activated and unactivated secondary alkyl halides catalyzed by a nickel/norephedrine complex
Strotman, Neil A.,Sommer, Stefan,Fu, Gregory C.
, p. 3556 - 3558 (2008/02/14)
(Chemical Equation Presented) An active partner: Nickel in combination with an amino alcohol ligand (norephedrine) was found to provide the most versatile and efficient catalyst for Hiyama cross-coupling reactions of alkyl electrophiles that has been described to date. Unprecedented Hiyama reactions of activated secondary alkyl bromides were achieved, as were the first Hiyama couplings of (activated) alkyl chlorides (see scheme, X = Br, Cl; HMDS = 1,1,1,3,3,3-hexamethyldisilazane, DMA = N,N-dimethylacetamide).
