65797-54-8Relevant academic research and scientific papers
Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol
Zhao, He,Zhao, Shuo,Li, Xiu,Deng, Yinyue,Jiang, Huanfeng,Zhang, Min
supporting information, p. 218 - 222 (2019/01/10)
A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.
Discovery and optimization of a novel series of liver X receptor-α agonists
Li, Leping,Liu, Jiwen,Zhu, Liusheng,Cutler, Serena,Hasegawa, Hirohiko,Shan, Bei,Medina, Julio C.
, p. 1638 - 1642 (2007/10/03)
A novel series of hexafluorocarbinols were discovered as potent activators of the liver X receptor-α using a fluorescence polarization assay. Structure-activity relationship study led to the identification of compounds that are more potent agonists than t
Polyfluorohydroxyisopropyl-heterocyclic compounds
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, (2008/06/13)
Polyfluorohydroxyisopropyl: -indolines, -tetrahydroquinolines, and -benzazepines, such a α,α-bis(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-6-methanol, useful as intermediates for antihypertensives.
