65797-85-5

Basic information

• Product Name: 2-(4-(ETHYLAMINO)PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL
• Synonyms: 2-(4-(ETHYLAMINO)PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL
• CAS NO: 65797-85-5
• Molecular Formula: C₁₁H₁₁F₆NO
• Molecular Weight: 287.2
• Mol File: 65797-85-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 93-94 °C(Solv: hexane (110-54-3))
• Boiling Point: 308.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.395±0.06 g/cm3(Predicted)
• PKA: 9.81±0.15(Predicted)
• CAS DataBase Reference: 2-(4-(ETHYLAMINO)PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(ETHYLAMINO)PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL(65797-85-5)
• EPA Substance Registry System: 2-(4-(ETHYLAMINO)PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL(65797-85-5)

Safety Data

• Hazardous Substances Data: 65797-85-5(Hazardous Substances Data)

Upstream product

• 52225-57-7 2,2,2-trifluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl) ethylidene}acetamide 
• 103-69-5 N-ethyl-N-phenylamine 
• 684-16-2 Hexafluoroacetone 
• 1992-24-1 N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-acetamide 
• 722-92-9 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 108-24-7 acetic anhydride 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 

Downstream Products

• 892225-03-5 C₁₈H₁₅F₆NO₂ 
• 1425493-12-4 C₁₇H₁₄F₆N₂O₅S 
• 1186132-57-9 C₁₈H₁₄F₆INO₂ 
• 872690-52-3 2-{4-[ethyl-(thiazol-4-ylmethyl)-amino]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol 
• 872690-50-1 2-[4-(ethyl-phenethyl-amino)-phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol 
• 872690-77-2 2-(4-{[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-ethyl-amino}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol 
• 872690-76-1 2-(4-{ethyl-[5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-amino}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol 

Relevant articles and documents

C-ALKYLATION OF N-ALKYLANILINES BY POLYFLUOROKETONES

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Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol

A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.

Synthesis and inhibitory activity on hepatitis C virus RNA replication of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analogs

Using our recently developed assay system for full-genome-length hepatitis C virus (HCV) RNA replication in human hepatoma-derived Li23 cells (ORL8), we identified 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analog 1a as a novel HCV inhibitor. St