65798-34-7

Basic information

• Product Name: L-Cysteine, S-(1,1-dimethylethyl)-N-[(2-nitrophenyl)thio]-, compd. with N-cyclohexylcyclohexanamine (1:1)
• CAS NO: 65798-34-7
• Molecular Formula: C13H18N2O4S2.C12H23N
• Molecular Weight: 511.75
• Mol File: 65798-34-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Cysteine, S-(1,1-dimethylethyl)-N-[(2-nitrophenyl)thio]-, compd. with N-cyclohexylcyclohexanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cysteine, S-(1,1-dimethylethyl)-N-[(2-nitrophenyl)thio]-, compd. with N-cyclohexylcyclohexanamine (1:1)(65798-34-7)
• EPA Substance Registry System: L-Cysteine, S-(1,1-dimethylethyl)-N-[(2-nitrophenyl)thio]-, compd. with N-cyclohexylcyclohexanamine (1:1)(65798-34-7)

Safety Data

• Hazardous Substances Data: 65798-34-7(Hazardous Substances Data)

Upstream product

• 7669-54-7 2-nitrobenzenesulfenyl chloride 
• 2481-09-6 S-tert-Butyl-N-acetyl-L-cysteine hydrochloride 
• 65798-33-6 N-<(2-Nitrophenyl)-sulfenyl>-S-tert-butyl-L-cysteine 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Downstream Products

• 76499-11-1 <-S-tert-butyl-L-cysteinyl>-L-phenylalanine tert-Butyl Ester 

Relevant articles and documents

tert-Butyl group as thiol protection in peptide synthesis

S-tert-Butylcysteine was obtained by a new method. A number of its N-protected derivatives and esters were synthesized. Syntheses of several peptides containing tert-butyl and acetamidomethyl or benzyl thioethers of cysteine were carried out. The tert-butyl group was removed from the thiol group of peptides by treatment with (2-nitrophenyl)sulfenyl chloride (NpsCl). The S-(2-nitrophenyl)sulfenyl derivatives so obtained were converted either into cysteine by reduction or into cystine derivatives by disproportionation. Owing to the mild deprotection conditions and the great stability of the S-tert-butyl group, the other protecting groups, particularly those of the thiols, could be easily removed from a variety of combinations.