658063-45-7Relevant academic research and scientific papers
Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis
Molinaro, Carmela,Guilbault, Audrey-Anne,Kosjek, Birgit
supporting information; experimental part, p. 3772 - 3775 (2010/11/16)
A practical procedure for the enzymatic resolution of 2-alkyl-2-aryl- disubstituted epoxides using the Codex HHDH P2E2 enzyme and sodium azide is reported. This method allowed the synthesis of novel regio-and enantioselective 1-azido-2-arylpropan-2-ols in
Catalytic asymmetric synthesis of 2,2-disubstituted oxetanes from ketones by using a one-pot sequential addition of sulfur ylide
Sone, Toshihiko,Lu, Gang,Matsunaga, Shigeki,Shibasaki, Masakatsu
supporting information; experimental part, p. 1677 - 1680 (2009/06/30)
(Chemical Equation Presented) Better the second time around: The title compounds were synthesized by using a one-pot double methylene transfer catalyzed by a heterobimetallic La/Li complex. Chiral amplification in the second step was the key to obtaining
Catalytic asymmetric synthesis of 2,2-disubstituted terminal epoxides via dimethyloxosulfonium methylide addition to ketones
Sone, Toshihiko,Yamaguchi, Akitake,Matsunaga, Shigeki,Shibasaki, Masakatsu
supporting information; experimental part, p. 10078 - 10079 (2009/02/04)
Catalytic asymmetric Corey-Chaykovsky epoxidation of ketones with dimethyloxosulfonium methylide 2 using an LLB 1a + Ar3P=O complex proceeded smoothly at room temperature, and 2,2-disubstituted terminal epoxides were obtained in high enantioselectivity (91-97%) and yield (>88-99%) from a broad range of methyl ketones with 1-5 mol % catalyst loading. The use of achiral additive Ar3P=O 5i was important to achieve high enantioselectivity. Copyright
