65826-99-5

Usage

Derived from

Indole (a heterocyclic organic compound)

Usage

Synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Potential applications

Development of new drugs and scientific research

Chemical properties

Exhibits interesting chemical properties with implications in various fields of chemistry and biochemistry.

Upstream product

• 75-29-6 isopropyl chloride 
• 104177-71-1 o-isopentylaniline 
• 27125-61-7 2-(3-methylbut-2-en-1-yl)aniline 
• 60173-64-0 N-(1,1-dimethylprop-2-en-1-yl)aniline 
• 861216-48-0 tert-butyl 2-methylbut-3-en-2-yl carbonate 
• 62-53-3 aniline 
• 17790-93-1 2-isopropyl-1H-indole 
• 496-15-1 1-indoline 
• 615-43-0 2-iodophenylamine 
• 598-23-2 3-methyl-but-1-yne 
• 174275-12-8 2-(3-methyl-1-butynyl)aniline 

Downstream Products

• 1143570-96-0 (+)-(S)-2-isopropylindoline 

Relevant academic research and scientific papers

Iron-Catalyzed Intramolecular Aminations of C(sp3)?H Bonds in Alkylaryl Azides

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of unactivated C(sp3)?H bonds in alkylaryl azides, which results in the formation of substituted indoline and tetrahydroquinoline derivatives.

Kinetic Resolution of 2-Substituted Indolines by N-Sulfonylation using an Atropisomeric 4-DMAP-N-oxide Organocatalyst

The first catalytic kinetic resolution by N-sulfonylation is described. 2-Substituted indolines are resolved (s=2.6–19) using an atropisomeric 4-dimethylaminopyridine-N-oxide (4-DMAP-N-oxide) organocatalyst. Use of 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycolic acid. A qualitative model that accounts for the stereodiscrimination is proposed.

NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

Kinetic resolution of indolines by Pd-catalyzed asymmetric ally Lie amination

The kinetic resolution of indolines was realized via a Pd-catalyzed allylic substitution reaction by using Trost's chiral ligand L10, affording optically active indolines and N-allylated indolines in high yields and high enantioselectivities with an 5 factor up to 59, which provided the first example for the kinetic resolution of nucleophiles via a transition-metal-catalyzed allylic substitution reaction. 2009 American Chemical Society.

Lithium N-lithioalkyldithiocarbamates: New N-alkylaminoalkyl anion equivalents IV; a new method for the preparation of 2-substituted indoline derivatives

Metalation of the 2-position in indolines is feasible via the dithiocarbamate derivative using s-butyllithium. In a one-pot procedure, treatment with alkyl halides, carbonyl compounds, oxiranes and imines leads to the corresponding 2-substituted indoline derivatives.