65833-22-9 Usage
Uses
Used in Biochemistry Research:
3,4-dichloro-1-(3,4-dichlorophenyl)-1H-pyrrole-2,5-dione is used as a redox indicator for monitoring electron transfer processes in various biochemical reactions. Its color change property allows for the visual assessment of redox states in experiments.
Used in Photosynthesis Experiments:
In the field of photosynthesis research, 3,4-dichloro-1-(3,4-dichlorophenyl)-1H-pyrrole-2,5-dione is used to measure the rate of electron transport in chloroplasts. This helps scientists understand the efficiency and mechanisms of photosynthetic processes in plants.
Used in Enzyme Assays:
3,4-dichloro-1-(3,4-dichlorophenyl)-1H-pyrrole-2,5-dione is utilized in enzyme assays to determine the presence of antioxidants. Its ability to accept electrons makes it a useful tool for identifying and studying antioxidant activity in biological systems.
Used in the Study of Redox Reactions:
This chemical compound is employed in the investigation of redox reactions, which are essential for various biological processes. Understanding these reactions can provide insights into cellular metabolism, energy production, and the role of antioxidants in protecting against oxidative stress.
Used in the Study of Oxidative Stress:
3,4-dichloro-1-(3,4-dichlorophenyl)-1H-pyrrole-2,5-dione is also used in research focused on oxidative stress, a condition that can lead to cell damage and contribute to various diseases. By studying the interactions of 3,4-dichloro-1-(3,4-dichlorophenyl)-1H-pyrrole-2,5-dione with antioxidants, scientists can gain a better understanding of the mechanisms involved in oxidative stress and develop potential therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 65833-22-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,8,3 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 65833-22:
(7*6)+(6*5)+(5*8)+(4*3)+(3*3)+(2*2)+(1*2)=139
139 % 10 = 9
So 65833-22-9 is a valid CAS Registry Number.
65833-22-9Relevant academic research and scientific papers
METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS
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Page/Page column 44; 49, (2014/06/23)
The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have p
An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity
Budke, Brian,Kalin, Jay H.,Pawlowski, Michal,Zelivianskaia, Anna S.,Wu, Megan,Kozikowski, Alan P.,Connell, Philip P.
, p. 254 - 263 (2013/02/23)
Homologous recombination (HR) is an essential process in cells that provides repair of DNA double-strand breaks and lesions that block DNA replication. RAD51 is an evolutionarily conserved protein that is central to HR. Overexpression of RAD51 protein is
Inhibition of Bfl-1 with N-aryl maleimides
Cashman, John R.,MacDonald, Mary,Ghirmai, Senait,Okolotowicz, Karl J.,Sergienko, Eduard,Brown, Brock,Garcia, Xochella,Zhai, Dayong,Dahl, Russell,Reed, John C.
supporting information; experimental part, p. 6560 - 6564 (2010/12/24)
High-throughput screening of 66,000 compounds using competitive binding of peptides comprising the BH3 domain to anti-apoptotic Bfl-1 led to the identification of 14 validated 'hits' as inhibitors of Bfl-1. N-Aryl maleimide 1 was among the validated 'hits'. A chemical library encompassing over 280 analogs of 1 was prepared following a two-step synthesis. Structure-activity studies for inhibition of Bfl-1 by analogs of N-aryl maleimide 1 revealed a preference for electron-withdrawing substituents in the N-aryl ring and hydrophilic amines appended to the maleimide core. Inhibitors of Bfl-1 are potential development candidates for anti-cancer therapeutics.
