65845-56-9

Usage

Uses

3-(Methylamino)propanoic acid HCl

Upstream product

• 17946-01-9 methyl 3-propanoate 
• 24549-12-0 methyl 3-(methylamino)propanoate 

Downstream Products

• 1443255-32-0 3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylmethylamino]propanoic acid 

Relevant academic research and scientific papers

SULFOXIDE-BASED REAGENT FOR MASS SPECTROMETRY

The present invention relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry

Modern proteomics requires reagents for exact quantification of peptides in complex mixtures. Peptide labelling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that separate in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical molecular weight but a different mass of the reporter groups, allowing relative quantification of multiple samples in one measurement. Here we report a new isobaric labelling reagent, where the balancer and the reporter are linked by a sulfoxide group, which, based on the sulfoxide pyrolysis, leads to easy and asymmetric cleavage at low fragmentation energy. The fragmentation of our new design is significantly improved, yielding more intense complementary ion signals, allowing complementary ion cluster analysis as well.

Synthesis of 64CuII- bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: In vivo evaluation as dual-modality PET-MRI agent

A novel bifunctional chelator combines a dithiocarbamate group for binding the positron-emitter 64Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI cont

BISPHOSPHONATE COMPOUNDS FOR CHELATING RADIONUCLIDES

Bisphosphonate compounds for chelating radionuclides are described which have separate bisphosphonate and metal chelating groups joined by a linker, so that the bisphosphonate groups are available to complex to hydroxyapatite in bone, while the metal chelating group binds to the radionuclide. This avoids problems in the prior art, where the bisphosphonate groups are used for both binding functions which compromises the bone-seeking activity of the bisphosphonate groups when they are used to chelate the radionuclide.